冠心病患者血清γ-谷氨酰转肽酶水平与Gensini评分的相关性研究  

Association between Serum Gamma-glutamyl Tansferase Levels and Gensini Score in the Patients with Coronary Heart Disease

作　　者：张放[1] 安浩君 李霞 张志强[1] 王志军[1] 

机构地区：[1]河北联合大学附属医院心血管内科二病区,河北省唐山市063000 [2]唐山市工人医院心血管内科一病区

出　　处：《中国全科医学》2014年第35期4166-4169,共4页Chinese General Practice

摘　　要：目的探讨冠心病患者血清γ-谷氨酰转肽酶(GGT)水平与Gensini评分的相关性。方法选择2012年2月—2012年12月在唐山市工人医院心内一科住院行冠状动脉造影检查并确诊的冠心病患者190例。根据GGT四分位数将患者分为4组〔第1四分位组(GGT≤17 U/L)、第2四分位组(17 U/L<GGT≤22 U/L)、第3四分位组(22 U/L<GGT≤30 U/L)、第4四分位组(>30 U/L)〕,对各变量进行趋势分析;收集患者临床资料,进行相关生化检查,行冠状动脉造影术并进行Gensini评分。结果 4组年龄、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、肌酐(Cr)、尿酸(UA)、Gensini评分、行经皮冠状动脉介入治疗(PCI)手术率、吸烟率比较,差异均有统计学意义(P<0.05)。第4四分位组TC、LDL-C、Cr、UA、Gensini评分高于第1四分位组和第2四分位组(P<0.05);第3四分位组TC、Gensini评分高于第1四分位组和第2四分位组(P<0.05)。血清GGT水平与Gensini评分、年龄、TC、TG、LDL-C、Cr、UA水平呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关(P<0.05)。多元线性回归分析显示,Gensini评分的升高与血清GGT水平的升高存在剂量-反应关系,在校正冠心病相关危险因素后,冠状动脉Gensini评分均进入回归方程,随血清GGT水平的升高而增加(P<0.05)。结论校正冠心病相关危险因素后,血清GGT水平与Gensini评分呈正相关,血清GGT水平升高可能是冠心病的危险因素,为临床进一步研究提供了理论依据。Objective To study the association between level of serum gamma-glutamyltansferase（ GGT） and coronary artery lesions in the patients with coronary heart disease. Methods 190 patients hospitalized in First Ward of Cardiology Department,Tangshan Gongren Hospital and diagnosed as coronary heart disease by coronary angiography were selected in February to December 2012 and divided by quartile of serum GGT（ 17 U / L,22 U / L,30 U / L） into four groups： the first quartile group（ GGT≤17 U / L）,the second quartile group（ 17 U / L〈 GGT≤22 U / L）,the third quartile group（ 22 U / L〈 GGT≤30U / L）,the fourth quartile group（〉 30 U / L）,respectively. Madding trend analysis of each variable,collected patients＇ clinical materials,performed related biochemical examination and coronary artery angiography and graded the severity with Gensini score. Results Age,total cholesterol（ TC）,triglyceride（ TG）,low density lipoprotein cholesterol（ LDL-C）,creatinine（ Cr）,uric acid（ UA）,Gensini score,Percutaneous coronary intervention（ PCI） operative rate,smoking rate of the four groups were statistically significant（ P〈0. 05）. TC,LDL-C,Cr,UA,Gensini score of the fourth quartile group were higher than those of the first and the second,with significant difference（ P〈0. 05）; TC,Gensini score of the third were higher than the first and the second,with significant difference（ P〈0. 05）; GGT levels of serum were positively correlated with Gensini score,age,TC,TG,LDL-C,Cr,UA levels and negatively with high density lipoprotein cholesterol（ HDL-C） level（ P〈0. 05）. Multiple linear regression analysis showed that there was a dose-response relationship between GGT level and Gensiniscore,and after correction of the risk factors of coronary diseases,Gensini score entered the regression equation and it was higher with the increase of GGT level（ P〈0. 05）. Conclusion There is a positive correlation between GGT and Gensini score after the correction of the risk facto

关 键 词：Γ-谷氨酰转移酶 GENSINI评分 冠心病 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]