手足口病患儿合并中枢神经系统损害临床分析  

Characteristic and treatment of children with hand-foot-mouth disease combined with central nervous system damage

作　　者：游勇[1] 廖华[2] 

机构地区：[1]湖北黄石市中心医院(湖北理工学院附属医院)新生儿科,黄石435000 [2]湖北黄石市中心医院(湖北理工学院附属医院)静脉调配中心,黄石435000

出　　处：《中国实用神经疾病杂志》2014年第22期20-22,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨手足口病患儿合并中枢神经系统损害的临床特点及治疗方法。方法选取合并中枢神经系统损害的手足口病患儿137例,随机分为2组。回顾分析所有患者的临床特点、试验时间、检查结果,并进行统计。2组患儿均实施综合治疗,在此基础上,对照组给予胞二磷胆碱静滴,观察组给予神经节苷脂静滴。对2组患儿神经系统好转时间、发热缓解时间及痊愈时间进行统计。于治疗10d时测定2组患儿神经元特异性烯醇化酶水平,评价2组患儿治疗效果。结果发热、皮疹、易惊是手足口病患儿合并中枢神经系统损害最为常见的临床表现;脑脊液细胞数升高是实验室检查中最常见的异常。观察组患者神经系统好转时间、发热缓解时间、痊愈时间及神经元特异性烯醇化酶水平均明显低于对照组。结论手足口病患儿合并中枢神经系统损害的临床表现缺乏特异性,治疗时应在综合治疗的基础上加用神经节苷脂静脉注射。Objective To investigate the characteristic and treatment of children with hand-foot-mouth disease （HFMD） combined with central nervous system damage （CNSD）. Methods One hundred and thirty-seven children with HFMD com-bined with CNSD were randomly divided into the control group （treated with citicoline infusion） and observation group （treated with ganglioside）. The nervous system improve time ,fever relieve time and recovery time of two groups were compared. The neuron-specific enolase levels of two groups were measured to evaluate the curative effect of two groups at 10 d after treatment.Results The fever ,rash ,hand-foot merger were the most common clinical manifestation of children with HFMD combined with CNSD ,and the increased cells in CSF were the most common laboratory abnormality. The nervous system improve time , fever relieve time ,recovery time and of neuron-specific enolase level of observation group were lower than these of control group.Conclusion The clinical characteristic of children with HFMD combined with CNSD has no specificity ,and the treat-ment methods should be comprehensive treatment plus intravenous ganglioside.

关 键 词：手足口病 中枢神经系统损害 

分 类 号：R512.5[医药卫生—内科学]