HBsAg、抗-HCV反应性无偿献血者归队检测模式探讨  

Study on rejoin detection mode for unpaid blood donors with HBsAgor anti-HCV positive reactivity

作　　者：曾劲峰[1] 陈云龙[1] 郑欣[1] 刘衡[1] 邬林枫[1] 杜丹丹[1] 

机构地区：[1]深圳市血液中心,广东深圳518035

出　　处：《国际检验医学杂志》2014年第23期3207-3209,共3页International Journal of Laboratory Medicine

摘　　要：目的：探讨深圳地区无偿献血人群因血液筛查检测 HBsAg 或抗-HCV 呈阳性反应，在规定的条件下允许其再次招回重新检测，以确定是否恢复其献血资格并重新归队献血的检测模式。方法对深圳市2007年10月至2013年12月期间无偿献血人群捐血后 HBsAg、抗-HCV 初筛反应性人员，且符合我中心制定的再次招回重新检测的献血人群进行分析研究，对无偿献血者归队模式的可行性进行探讨。结果2007～2013年期间共计415759人次，HBsAg 检测阳性2506例，抗-HCV 检测阳性1357例，阳性率分别为0.60％和0.33％。笔者对符合召回条件的59例 HBsAg 和16例抗-HCV 阳性反应的多次献血者启动了归队检测的召回流程，HBsAg、抗-HCV 项目分别有31例和9例成功完成检测流程检测项。其中29例曾经 HBsAg 呈阳性反应的献血者重新恢复献血资格，2例因后续检测不合格被屏蔽献血资格，而9例曾经抗-HCV 阳性反应而召回献血者全部恢复其献血资格。结论在现有检测模式下，血液筛查的检测技术手段很难避免因试剂、设备、人员操作等原因造成假阳性反应的发生。为了保护无偿献血人群的献血资格，必须建立一套科学、合理并具有实际操作性的献血者归队检测模式，以保护有限的无偿献血资源。Objective To investigate the detection mode for those unpaid blood donors screening as positive HBsAg＋ and/or positive anti-HCV could be permitted to recall again for re-detection under the regulation condition in order to determine whether or not regain their qualifications of donating blood and rejoin the blood donation again.Methods The unpaid blood donors preliminari-ly screening as positive HBsAg and/or positive anti-HCV in Shenzhen from Otcober 2007 to December 2013 and conforming to the rules for recalling to re-detection formulated by our center were analyzed and researched for conducting the feasibility discussion on the rejoin mode of unpaid blood donors.Results A total of 415 759 case-times of blood donation were conducted during 2007 ~2013.Among them,2 506 cases（0.60%）and 1 357 cases（0.33%）were screened as positive HBsAg or positive anti-HCV,respec-tively.The recall process of rejoin re-detection was initiated in 59 positive HBsAg donors and 16 positive anti-HCV donors with many times of blood donation.But only 31 positive HBsAg donors and 9 positive anti-HCV donors successfully completed the detec-tion items of re-detection process.Among them 29 positive HBsAg donor regained the qualifications of donating blood and 2 cases were shielded for the blood donation qualification due to unqualification in the following detection.All of the 9 recalled donators with positive anti-HCV regained the blood donation qualification.Conclusion Under present detection mode,the detection tech-nique of blood screening is hard to avoid the occurrence of false positive results caused by the reagents,instruments and personnel operating.In order to protect the donation qualifications of the unpaid blood donators,a set of scientific,reasonable and practical re-detection mode for rejoin of the blood donators should be established for protecting the limited blood donation resource.

关 键 词：反应性 献血者归队 乙肝表面抗原 抗-HCV 

分 类 号：R446.6[医药卫生—诊断学]