正常老年人使用重组人生长激素替代治疗对其生活质量的影响及可行性  

Effect on quality of life and feasibility of using replacement therapy with recombinant human growth hormone on normal elderly

作　　者：侯佳彤[1] 于萍[1] 潘慧[1] 陈适[1] 

机构地区：[1]中国医学科学院 北京协和医学院 北京协和医院卫生部内分泌重点实验室,北京100730

出　　处：《中华临床医师杂志（电子版）》2014年第21期105-108,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：随着人口老龄化的加剧,衰老越来越受到人们的重视。衰老主要表现为行为能力、工作能力、肌肉质量以及生殖能力、性行为、性欲的降低,同时还会出现血脂水平增加,认知功能的损伤和睡眠障碍等。衰老相关的临床表现,降低了老年人的生活质量(QoL),其中有很多表现与生长激素缺乏患者的表现相似。近年来关于使用重组人生长激素(rhGH)替代治疗来延缓衰老的研究有很多。研究显示rhGH可以改善老年人的生活质量。本文将从生活质量的定义、测量,老年人身体各系统与生长激素(GH)的关系以及rhGH可能的作用机制来阐述rhGH替代治疗对正常老年人生活质量的影响和可行性。With the increasing population of the aged, more and more people pay attention to aging, which may cause the behavior ability, work ability, muscle mass, the reproductive capacity, sexual behavior and libido to decrease, meanwhile, there will be increased blood lipid level, sleeping disorders, cognitive impairment etc. Aging-related clinical manifestations reduce the elder＇s quality of life （QoL）, which are similar to the performance of patients with growth hormone deficiency. There are many researches about using recombinant human growth hormone （rhGH） to slow down the aging progress. Studies have shown that rhGH can improve the QoL of old persons. This paper explained the definition and measurement of QoL, the relationship between the body systems of the old and growth hormone （GH）, the possible mechanism ofrhGH and the effects and feasibility ofrhGH replacement therapy on QoL in normal aged ones.

关 键 词：生长激素 激素替代疗法 生活质量 老年人 

分 类 号：R459.1[医药卫生—治疗学]