阿苯达唑与12-磷钨酸相互作用的共振瑞利散射、二级散射与倍频散射光谱及其应用  

Study on Interaction of 12-Tungstophosphoric Acid with Albendazole by Resonance Rayleigh Scattering,Second-order Scattering and Frequency Doubling Scattering Spectra and Their Analytical Application

作　　者：李勤 田丰玲 郑小波 李金 杨季冬[3] 

机构地区：[1]重庆市医药卫生学校,重庆408000 [2]西南大学化学化工学院,重庆400715 [3]重庆三峡学院化学与环境工程学院,重庆404100

出　　处：《分析测试学报》2014年第12期1362-1367,共6页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(21175015);重庆市涪陵区科委资助项目(FLKJ;2013ABB2088)

摘　　要：采用共振瑞利散射(RRS)、二级散射(SOS)和倍频散射(FDS)光谱研究了阿苯达唑(ABZ)与12-磷钨酸(TP)的相互作用。在盐酸(p H 1.2)介质中,ABZ与TP反应形成离子缔合物(nABZ:nTP=3∶1),使RRS、SOS与FDS的光谱信号大大增强。在一定范围内,散射强度(ΔI)与ABZ的浓度成正比。对于ABZ的检出限(3σ)分别为1.98μg/L(RRS法)、3.75μg/L(SOS法)、5.07μg/L(FDS法),其中RRS法的灵敏度最高。文中讨论了ABZ与TP的最佳反应条件、影响因素以及共存物质的影响,还讨论了离子缔合物的结构和反应历程。据此发展了一种用RRS法快速、简便、灵敏测定ABZ的新方法。A method for the determination of albendazole （ABZ） by resonance Rayleigh scattering （RRS）,second-order scattering （SOS） and frequency doubling scattering （FDS） at the nanogram level using 12-tungstophosphoric acid（TP） was presented.It was found that ABZ could react with TP and form an ion-association complex by 3：1 in pH 1.2 HC1 medium,which induced the enhancement of RRS,SOS and FDS intensities.In certain ranges,the increments of scattering intensity （AI） were directly proportional to the concentrations of ABZ.The detection limits （3σ） for ABZ were 1.98 μg/L（RRS）,3.75 μg/L（SOS） and 5.07 μg/L（FDS）,respectively.The sensitivity of RRS method was higher than that of SOS and FDS methods.The optimum conditions of RRS method and the influencing factors were discussed.In addition,the composition of ion-association complex and the reaction mechanism were investigated.With a good selectivity,the method was successfully applied for the determination of ABZ in tablets and human urine samples with satisfactory results.

关 键 词：共振瑞利散射 二级散射 倍频散射 阿苯达唑 12-磷钨酸 

分 类 号：O561.3[理学—原子与分子物理] TQ460.72[理学—物理]