多维健康评定量表在中国系统性红斑狼疮人群中的信度及效度研究  

Reliability and validity of the multi-dimensional health assessment questionnaire in patients with systemic lupus erythematosus in China

作　　者：宋洋[1] 吕良敬[1] 

机构地区：[1]上海交通大学医学院附属仁济医院风湿科,200001

出　　处：《中华风湿病学杂志》2015年第1期4-9,共6页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（81373209,81072469,30671946）;上海市自然科学基金（09ZR1417600）

摘　　要：目的 评估中文版多维健康评定量表（MDHAQ-C）在中国SLE人群生活质量测量中的信度及效度.方法 招募SLE患者1 12例,信度分析采用组内相关系数（ICC）重测信度及克隆巴赫系数α内部一致性评估.聚合效度通过比较MDHAQ各维度得分与健康评定问卷（HAQ）、医院焦虑抑郁量表（HAD）及简明健康状况调查表（SF-36）的Spearman相关分析进行评估相关性评价.区分效度通过比较不同组别患者各维度得分差异进行Mann-Whitney检验进行分析.结果 在维度层面,克隆巴赫系数α分别为0.886及0.774;在条目层面,条目校正的项总计相关系数0.409～0.866.重测信度各维度组内相关系数值ICC范围0.615～0.920（P＜0.05）.MDHAQ中文版大部分维度与HAQ、HAD及SF-36的相关性较好（P＜0.5至P＜0.001）.针对不同疾病活动度及损伤程度的患者,MDHAQ不同维度得分差异有统计学意义（P＜0.05）区分效度.结论 MDHAQ中文版信度、效度良好,可作为躯体功能及生活质量的测评工具,用于中国SLE人群.Objective To evaluate the reliability and validity of Chinese multi-dimensional health assessment questionnaire （MDHAQ-C） in patients with systemic lupus erythematosus （SLE） in China.Methods One hundred and twelve SLE patients were recruited in the evaluation.The reliability of the questionnaire was tested by intra-class coefficient （ICC） and Cronbach＇s alpha.Convergent validity and divergent validity were assessed by Spearman correlation coefficient of MDHAQ-C with health assessment questionnaire （HAQ）,the 36-item short-form health survey （SF-36） and the hospital anxiety and depression scales（HAD）.Discriminant validity was tested in groups of patients with varied disease activities and status of damage.Results The Cronbach＇s alpha was 0.886 in the function scale （FN） and 0.774 in the scale of psychological status （PS）.The corrected item-total correlation ranged from 0.409-0.866.The ICC was 0.615-0.920（P＜0.05）.MDHAQ-C correlated with the questionnaires satisfyingly in most scales （from P＜0.5 to P＜0.001）.The scores of MDHAQ-C could discriminate different groups of patients （P＜0.05）.Conclusion MDHAQ-C is a reliable,valid instrument for functional measurement and quality of life assessment in Chinese SLE patients.

关 键 词：红斑狼疮 系统性 生活质量 信度 效度 

分 类 号：R593.241[医药卫生—内科学]