腹侧被盖区多巴胺能神经元对奖赏/厌恶刺激反应的异质性  

Heterogenicity of Dopaminergic Neurons Within The Ventral Tegmental Area in Reward and Aversion

作　　者：杨晓娜[1] 张红星[1] 刘鹤[1,2] 曹君利[1,2] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室,徐州221004 [2]徐州医学院附属医院麻醉科,徐州221004

出　　处：《生物化学与生物物理进展》2015年第1期41-48,共8页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金重点项目(81230025);国家自然科学基金面上项目(81070888);国家自然科学基金青年基金(81200862;81300957)资助项目~~

摘　　要：中脑多巴胺奖赏系统,由腹侧被盖区及其投射靶区组成,参与药物依赖、精神疾病等病理过程的调控.奖赏和厌恶刺激是衡量上述病理过程的重要手段.一直以来,不同研究在该系统对奖赏和厌恶刺激的反应上存在分歧,越来越多的研究倾向于认为该系统,特别是腹侧被盖区多巴胺能神经元存在较大的异质性.本文从腹侧被盖区多巴胺能神经元判定标准、解剖定位和投射特异性等角度对其在奖赏和厌恶刺激中的功能异质性进行综述,并对未来研究方向进行展望.The mesolimbic reward system, consisting, at its core, of the ventral tegmental area and its downstream targeting brain areas, has historically been investigated for its role in drug addiction and neuropsychological disorders. Award and aversion stimuli are two widely-used measurements in these pathological processes in animal studies. Huge divergence does exist in the responses of this system to award or aversive stimuli, and more and more studies tend to agree that the midbrain reward system, especially the dopaminergic neurons within the ventral tegmental area has great heterogenicity. Focusing on the identification criteria, anatomical location and projection-specification of dopaminergic neuron, this review summarized the heterogeneous responses to reward/aversion, and looked into the directions of future studies.

关 键 词：腹侧被盖区 多巴胺 奖赏 厌恶 异质性 

分 类 号：R395.3[哲学宗教—心理学] R395.4[医药卫生—医学心理学]