一级微铜圈肾动脉栓塞的实验研究  

Renal artery embolization with first level copper coils: an experimental study

作　　者：姜华[1] 闫东[1] 孙勇[1] 濮进敏[1] 王家平[1] 李迎春[1] 童玉云[1] 赵洁[1] 

机构地区：[1]昆明昆明医科大学第二附属医院放射科介入室,650101

出　　处：《介入放射学杂志》2015年第1期64-68,共5页Journal of Interventional Radiology

摘　　要：目的评价一级微铜圈在动物体内的栓塞性能和生物相容性。方法用直径0.1~0.23 mm导电用铜丝（纯度99.9%）制成直径0.48~0.74 mm的一级微铜圈,经3 F微导管释放栓塞兔肾动脉末梢支,于栓塞术后不同时间观察血管闭塞情况和病理学改变,同时对实验动物栓塞前后的实验室检查指标进行比较。结果栓塞术后3 d,1、2、4、6和12周,动脉造影血管管腔闭塞时可见到血栓形成。栓塞后4周,组织学检查均可见小动脉内微球,动脉周围有炎性反应,并可见肾实质梗死灶;栓塞术后,血清铜离子术后2周内较术前升高,差异有统计学意义（P〈0.05）,术后4周与术前比较,差异无统计学意义（P〉0.05）;肝、肾功能2周后恢复至术前水平。结论自制一级微铜圈具有明确的栓塞效果和良好的生物相容性。Objective To evaluate the embolization effect and biocompatibility of self- made first level copper coils in experimental animal in vivo. Methods First level of pure copper micro-coil（Φ： 0.48- 0.74 mm）,which was made of 0.1- 0.23 mm diameter pure copper wire, was used in this study. Renal artery embolization with first level pure copper coil was performed through a 3 F catheter in rabbits. After the embolization, the arteriography and the pathological examination were carried out at different points of time.Hematological and biochemical examinations, including the serum level of copper ions, the hepatic and renal function tests, were conducted before and after embolization. The results were analyzed. Results Three days,and one, 2, 4, 6, 12 weeks after the embolization, arteriography was performed, which showed that the vascular lumen was obstructed with thrombus in all experimental rabbits. Four weeks after embolization,micro- spheres could be seen within the embolized small arteries, and inflammatory reactions could be noted around the arteries. Infarction focus was demonstrated in the renal parenchyma. Two weeks after the treatment, the serum level of copper ions was significantly increased when compared with preoperative one（P〈0.05）, but four weeks after the embolization the serum level of copper ions was not significantly different from the preoperative one（P〉0.05）. Two weeks after the embolization, both the renal and hepatic functions restored to preoperative levels. Conclusion Self- made first level copper coils have definite embolization effect and satisfactory biocompatibility.

关 键 词：弹簧圈 金属铜 栓塞 动脉 肾脏 家兔 

分 类 号：R543.5[医药卫生—心血管疾病]