呼吸道定植菌对人类偏肺病毒感染患儿喘息的影响  

Impact of colonized bacteria in respiratory tract on wheezing in children infected with human metapenumovirus

作　　者：李玲[1] 王宇清[1] 陈正荣[1] 严永东[1] 邵雪君[1] 孙慧明[1] 季伟[1] 

机构地区：[1]苏州大学附属儿童医院呼吸病科,江苏省215003

出　　处：《江苏医药》2015年第1期47-49,共3页Jiangsu Medical Journal

基　　金：江苏省社会发展项目(BE2012652)

摘　　要：目的探讨呼吸道定植菌对人类偏肺病毒(hMPV)感染患儿喘息的影响。方法收集531例hMPV感染患儿鼻咽分泌物,RT-PCR检测hMPV,普通痰培养法检测细菌,观察肺炎链球菌(SP)、流感嗜血杆菌(HI)、卡他莫拉菌(MC)和金黄色葡萄球菌(SA)定植情况。分析四种定植菌与hMPV感染患儿临床表现的关系。结果 hMPV感染患儿中,SP、HI、MC和SA定植主要见于3岁以下患儿,无明显性别差异。定植菌阳性组喘息发生率高于定植菌阴性组(73.6%vs.49.1%)(P<0.05)。细菌(主要是SP、HI和MC)定植与hMPV感染患儿喘息症状相关(OR=3.27,P<0.01)。结论鼻咽部定植菌,尤其是SP、HI、MC,对hMPV感染患儿的喘息症状有重要影响。Objective To explore the impact of colonized bacteria in respiratory tract on wheezing in the children infected with human metapenumovirus（hMPV）.Methods The hMPV and bacteria in nasopharyngeal secretion samples of 531 children with hMPV infection were detected by RT-PCR and common sputum culture method repectively.Streptococcus pneumoniae（SP）,hemophilus influenza（HI）,moraxella catarrhalis（MC）and staphylococcus aureus（SA）were observed,and relationship between four colonized bacteria and clinical manifestations was analyzed.Results The bacteria colonization of SP,HI,MC and SA was seen mainly in the children less than 3years old,which had no significant difference in gender.The incidence rate of wheezing was higher in the children with colonized bacteria positive than that in those with colonized bacteria negative（73.6% vs.49.1%）（P〈0.05）.The bacteria colonization,mainly SP,HI and MC,was correlated to wheezing in children with hMPV infection（OR=3.27,P〈0.01）.Conclusion Bacterial colonization has an important impact on the occurrence of wheezing in the children with hMPV infection,especially SP,HI and MC.

关 键 词：人类偏肺病毒 定植菌 喘息 

分 类 号：R725[医药卫生—儿科]