环二腺苷酸(c-di-AMP)--细菌的一种新型第二信使  

Cyclic diadenosine monophosphate——a new second messenger in bacteria-A review

作　　者：杜斌[1] 孙建和[1] 

机构地区：[1]上海交通大学农业与生物学院上海市兽医生物技术重点实验室,上海200240

出　　处：《微生物学报》2015年第2期126-133,共8页Acta Microbiologica Sinica

基　　金：国家自然科学基金项目(31172381,31372500);上海市基础研究重点项目(12JC1404700);上海市科技兴农重点攻关项目(2014-3-1)~~

摘　　要：环二腺苷酸(cyclic diadenosine monophosphate,c-di-AMP)是在细菌中新发现的一种第二信使分子,其参与调节多种生理功能,包括细菌的生长、细胞壁的代谢平衡以及细菌的致病力等。c-di-AMP除了在细菌中发挥作用外,它还可作为第二信使分子被真核宿主识别,激活先天性免疫应答。细菌细胞内c-di-AMP的代谢受二腺苷酸环化酶(diadenylate cyclase,DAC)和磷酸二酯酶(phosphodiesterase,PDE)的调控。本文综述了c-di-AMP的代谢途径、调控机制、受体蛋白、生物学功能以及未来的研究方向和应用前景。Cyclic diadenosine monophosphate（ c-di-AMP）,a new second messenger found recently in bacteria,regulates various aspects of bacterial physiology,including cell growth,cell wall homeostasis and virulence. In addition to its functions in bacterial physiology,c-di-AMP represents a putative bacterial secondary signaling molecule sensed by eukaryotic host cells and triggers innate immunity. The level of c-di-AMP in bacteria is regulated by the activities of diadenylate cyclase（ DAC） and phosphodiesterases（ PDE）,the former harbors a Dis A_N domain,and the latter a DHH or DHH / DHHA1 domain. This review gives an overview on metabolic pathway,regulatory mechanism,receptor proteins and biological function of c-di-AMP in bacteria,as well as its application and trends of development.

关 键 词：环二腺苷酸 第二信使 二腺苷酸环化酶 磷酸二酯酶 细菌信号转导 

分 类 号：Q933[生物学—微生物学]