社区非糖尿病人群颈围和胰岛素抵抗的相关性分析  

Relationship between neck circumference and insulin resistance in a community population

作　　者：王玉[1] 梁军[2] 腾飞[1] 邹彩艳[1] 刘学奎[1] 张倩[3] 卞文[4] 李洪艳[1] 邱勤勤 

机构地区：[1]徐州市中心医院内分泌科,221009 [2]徐州市中心医院内分泌科、徐州市医学科学研究所、徐州市糖尿病研究所 [3]徐州医学院徐州临床学院 [4]东南大学医学院

出　　处：《中华内分泌代谢杂志》2015年第1期33-36,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：江苏省卫生厅资助（H201356）

摘　　要：目的 分析和探索中国社区人群健康成人的颈围和胰岛素抵抗的相关性.方法 选择常住江苏徐州地区的社区健康人群2 31 8名为研究对象,检测受试者颈围、身高、腰围、臀围、体重和甘油三酯、总胆固醇、高密度脂蛋白胆固醇（H DL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖和餐后2 h血糖等相关生化指标.胰岛素抵抗以稳态模型评估的胰岛素抵抗指数（HOMA-IR）来评价.结果 颈围和年龄、体重指数（BMI）、腰围、臀围、腰臀比、收缩压、舒张压、甘油三酯、总胆固醇、LDL-C、尿酸正相关,与HDL-C负相关.校正年龄和其他心血管代谢危险因素后,无论男性和女性,颈围和HOMA-IR的增加趋势显著相关,进一步校正BMI和腰围后,这种相关性并没有明显变化.颈围和BMI或腰围对HOMA-IR有显著的叠加作用（P＜0.01）;在较大BMI和较大腰围的个体,颈围和HOMA-IR的相关性更明显.结论 在中国健康成人中,颈围和胰岛素抵抗、心血管代谢危险因素独立相关,并且和BMI、腰围有交互作用.Objective To investigate the relationship between neck circumference （NC） and insulin resistance in a large Chinese cohort of community population.Methods A total of 2 318 subjects in this study were from a community-based health examination survey in Xuzhou.Serum triglyceride（TG）,total cholesterol（TC）,high density lipoprotein-cholesterol （HDL-C）,low density lipoprotein-cholesterol （LDL-C）,and glucose levels were determined.NC,height,waist circumference （WC）,hip circumference,and body weight were measured.Insulin resistance was assessed by homeostasis model assessment-insulin resistance （HOMA-IR） index.Results NC was positively correlated with age,body mass index（BMI）,WC,hip circumference,waist-to-hip ratio,systolic blood pressure,diastolic blood pressure,uric acid,TC,TG,LDL-C,while negatively correlated with HDL-C.NC was significantly associated with increasing trend of HOMA-IR in both men and women after adjusting for age and other cardiometabolic risk factors.The associations still existed after further adjustment for BMI and WC.Moreover,there were significant interactions between NC and BMI or WC on HOMA-IR（P〈0.01）.The associations between NC and HOMA-IR appeared stronger among those with higher BMI or WC.Conclusions In healthy Chinese adults,NC is independently related to HOMA-IR and other cardiometabolic risk factors,and interacts with other parameters of overall or central adiposity,such as BMI and W,C.

关 键 词：颈围 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]