神经分化因子1 （Ala45Thr）基因多态性与2型糖尿病易感性关系的meta分析  

Meta-analysis of the relationship of NeuroD1 Ala45Thr polymorphism with type 2 diabetes

作　　者：木哈达斯·吐尔逊依明[1] 帕它木·莫合买提[1] 热伊拉·吾斯曼[1] 

机构地区：[1]新疆医科大学公共卫生学院劳动卫生与环境卫生学教研室,乌鲁木齐830011

出　　处：《中华内分泌代谢杂志》2015年第1期37-42,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目（81360127）

摘　　要：目的 通过meta分析评估神经分化因子1（Neuro1D1）Ala45Thr基因多态性与2型糖尿病的关联性.方法 通过系统检索PubMed、EMBASE、CNKI、万方数据库、维普数据库等中英文数据库,在Kavvoura等已发表1999年至2004年NeuroD1 （Ala45Thr）基因多态性与2型糖尿病关联性的meta分析基础上,纳入2004年至2012年有关NeuroD1 （Ala45Thr）基因多态性与2型糖尿病相关性的研究,以2型糖尿病组和正常对照组基因分布的OR值为统计量,应用Rev Man 5.0软件对研究结果进行异质性检验和相关数据的合并,最终纳入13篇病例对照试验文献.结果 共入选2型糖尿病患者3 896例,对照组3 186名.Meta分析结果显示,黄种人2型糖尿病与对照组Thr45Thr45/（Ala45Thr＋Ala45Ala45） OR值为3.16（95％CI0.99 ～10.11）,白种人OR值为1.09（95％ CI0.90～ 1.32）,差异均无统计学意义（P＞0.05） 而2型糖尿病组和对照组G/A等位基因频率OR值为0.85（95％ CI0.72 ～0.99）/1.18（95％ CI.07 ～ 1.38）,差异有统计学意义（Z=2.02,P=0.04）.结论 NeuroD1 （Ala45Thr）位点A等位基因可能是2型糖尿病的危险因素.Objective To investigate the association of neural differentiation factor 1 （NeuroD1） Ala45Thr polymorphism with type 2 diabetes by meta-analysis.Methods The electronic databases were retrieved from PubMed,EMBASE,CNKI,VIP fulltext database,and Wanfang fulltext database.Literatures about the association of NeuroD1 Ala45Thr polymorphism with type 2 diabetes from 2004 to 2012 were searched.The selected studies from 2004 to 2012 were included to analyze data based on the published meta-analysis of the NeuroD1 （Ala45Thr） gene polymorphism and type 2 diabetes written by Kavvoura,et al.The odds ratio of NeuroD1 （Ala45Thr） genotype distributions in type 2 diabetic patients compared with healthy control were analyzed.Rev-Man 5.0 software was applied for investigating hereogeneity among individual studies and summarizing effects with proper statistical methods.Thirteen case control studies were enrolled.Results A total of 3 896 patients and 3 186 control subjects were enrolled for the study.The pooled ORs of Thr45Thr45/（Ala45Thr＋ Ala45Ala45） genotype in type 2 diabetes mellitus and control groups were 3.16 （95% CI0.99-10.11） in the subgroup of yellow race and 1.09（95% CI0.90-1.32） in the subgroup of white race,with no statistically significant difference（P〉0.05）.The pooled OR of G/A allele in type 2 diabetes mellitus and control groups was 0.85 （95 % CI 0.72-0.99）/1.18 （95% CI 1.07-1.38）,with statistically significant difference （Z =2.02,P =0.04）.Conclusions The A allele of NeuroD1 （Ala45Thr） locus may be a risk factor for type 2 diabetes mellitus.

关 键 词：神经分化因子1 META分析 多态性 基因 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]