急性冠脉综合征患者颈动脉斑块与血清IL-6、sIL-6R的关系  

The Relationship between Carotid Artery Plaque of Acute Coronary Syndrome Patients and Serum IL-6,s IL-6R

作　　者：李靖[1] 李莉艳[1] 卢志强[1] 周帅[1] 牛方卿[1] 黄克钧[1] 

机构地区：[1]河南省胸科医院心九科,河南郑州450003

出　　处：《贵阳医学院学报》2015年第1期65-67,共3页Journal of Guiyang Medical College

摘　　要：目的:观察急性冠脉综合征(ACS)患者颈动脉斑块与血清白细胞介素-6(IL-6)和可溶性白细胞介素-6受体(s IL-6R)的关系。方法:85例ACS患者作为病例组,80例其它原因入院的冠心病患者作为对照组,彩色超声诊断仪检测颈动脉粥样斑块情况,ELISA法测定血清中的IL-6和s IL-6R水平,分析ACS患者颈动脉斑块稳定性与血清IL-6、s IL-6R水平的相关性。结果:病例组中具有颈动脉斑块不稳定斑块的患者比例明显高于对照组,差异具有统计学意义(P<0.05);病例组患者血清IL-6水平明显高于对照组,而s IL-6R水平明显低于对照组,差异有统计学意义(P<0.05);ACS患者血清IL-6水平与颈动脉斑块的不稳定性呈正相关关系(OR=3.85,P<0.05),ACS患者血清s IL-6R水平与颈动脉斑块的不稳定性呈负相关关系(OR=0.81,P<0.05)。结论:ACS患者IL-6和s IL-6R可作为预测ACS患者颈动脉粥样斑块稳定性的辅助指标。Objective： To observe the relationship of carotid artery plaque of acute coronary syndrome （ACS） patients and serum levels of interleukin-6 （IL-6） and soluble interleukin-6 receptor （sIL- 6R）. Methods： Eighty-five ACS patients were selected as case group, while 80 cases of hospitalized patients with coronary Doppler Uhrasonograph heart disease caused by other reasons were selected as control group. Color y （CDU） was used to detect carotid atherosclerotic plaque and serum IL- 6 and sIL- 6R levels were determined by ELISA. Then, the correlation of stability of carotid plaque and ser- um IL-6, sIL-6R levels of ACS patients was analyzed. Results： The proportion of unstable carotid ar- tery plaque in case group was significantly higher than that in control group （ P 〈 0.05 ） ; The level of serum IL-6 in case group was significantly higher than that in control group, while the sIL-6R level was significantly lower than that in control group （P 〈 0.05 ） ; There existed a positive correlation between the instability of carotid artery plaque and serum IL-6 levels （ OR = 3.85, P 〈 0.05 ）, while there ex- isted a negative correlation between the instability of carotid artery plaque and serum sIL- 6R levels （OR =0. 81, P 〈0.05 ）. Conclusion： IL-6 and sIL-6R can be used as an auxiliary index for predic- tion of stability of carotid artery plaque of ACS.

关 键 词：急性冠脉综合征 颈动脉斑块 白细胞介素6 可溶性白细胞介素6受体 

分 类 号：R541.4[医药卫生—心血管疾病]