近两年我院浅部真菌分布和深部酵母样真菌药敏情况分析研究  

Analysis research of superficial mycoses distribution and drug sensitivity of yeast-like fungi in deep in our hospital in the recent two years

作　　者：杨虹[1] 董晶[1] 吴波[2] 

机构地区：[1]北京大学深圳医院检验科,广东深圳518036 [2]北京大学深圳医院皮肤科,广东深圳518036

出　　处：《中国实验诊断学》2014年第6期916-918,共3页Chinese Journal of Laboratory Diagnosis

基　　金：深圳市科技计划资助项目(201202007)

摘　　要：目的分析我院皮肤科浅部真菌的分布情况和ICU深部真菌药敏结果及其菌种分布情况,为临床合理选用抗真菌药物提供依据。方法对我院2011年07月-2013年06月从皮肤科送检标本分离的浅部真菌的分布情况和从ICU分离的深部真菌分布情况及其药敏试验结果进行回顾性分析。结果皮肤科浅部真菌感染以毛癣菌属为主。ICU分离的深部真菌以白色酵母样真菌为主;未发现对两性霉素B和卡泊芬净耐药的酵母样真菌;白色酵母样真菌对5-氟胞嘧啶的敏感性达90.5%,对氟康唑、伊曲康唑和沃尔康唑的敏感性也都在80%以上;而非白色酵母样真菌对氟康唑敏感率为58.8%,而伊曲康唑的敏感率仅为41.2%。结论浅部真菌感染以毛癣菌属为主,深部真菌感染以白色酵母样真菌为主;白色酵母样真菌的药物敏感性高于非白色酵母样真菌。Objective To Analyze the distribution of superficial fungal in dermatology and susceptibility results of deep fungal strains and their distribution in ICU in our hospital in order to provide a basis for Clinical reasonable choice of antifungal drugs.Methods The retrospective analysis was performed to analyze the distribution of the superficial fungal from the specimens of the Dermatology,and susceptibility results of deep fungal strains from the specimens of ICU and their distribution.Results Superficial fungal infections of Dermatology was Trichophyton spp.primarily.Deep fungal infection of ICU was candida Albicans primarily;amphotericin B and caspofungin-resistant yeast-like fungi wasn’ t found;sensitivity of candida Albicans to 5-fluorocytosine was up to 90.5% and to fluconazole,itraconazole and vori-conazole was also more than 80%;while the sensitive rate of yeast-like fungi to Fluconazole was 58.8% and to itracon-azole was only 41.2 %.Conclusion Superficial fungal infection and deep fungal infection are given priority to with Trichophyton spp and Candida Albicans respectively;the candida Albicans＇s drug sensitivity is higher than other fun-gus.

关 键 词：浅部真菌 酵母样真菌 真菌药敏 

分 类 号：R519[医药卫生—内科学]