弥漫性轴索损伤患者血清NSE水平与CT表现及预后的相关性分析  

Correlation Analysis Between Serum NSE Levels with CT Manifestations and Prognosis in Patients with Diffuse Axonal Injury

作　　者：韩秋[1] 朱翔宇[1] 李靖[1] 杜叶平[1] 

机构地区：[1]徐州医学院附属淮安市第二人民医院,江苏淮安223002

出　　处：《中国实验诊断学》2014年第6期963-965,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨弥漫性轴索损伤(diffuse axonal injury DAI)患者血清神经元特异性烯醇化酶(Neuron Specific Enolase NSE)浓度与CT表现及患者预后的关系。方法 DAI患者86例和体检正常者16例,采用ELISA测定血清NSE浓度,统计、分析弥漫性轴索损伤患者血清NSE浓度的变化与CT表现及患者预后的关系。结果弥漫性轴索损伤患者血清NSE浓度较健康体检正常者显著升高(P<0.01)。脑池受压、移位>5mm患者血清NSE浓度显著高于移位<5mm的患者(P<0.01);预后不良组的血清NSE水平则明显高于预后良好组(P<O.01或P<0.05);死亡组病人NSE水平持续增高。结论弥漫性轴索损伤患者血清NSE浓度与脑池受压、移位程度显著相关,可作为一项生物标志物不仅可以评估急性脑外伤严重程度,还有助于判断预后。Objective Explore the correlation between serum （Neuron Specific Enolase）NSE levels withCT Mani- 〈br〉 festations and prognosis.in patients with diffuse axonal injury （DAI）.Methods 86 patients with DAI and 16 healthy patients,serum NSE levels wre measured by ELISA.Statistics and analysis of changes in serum concentrations of NSE compared with CT manifestations and patient prognosis.Results Compared with healthy people,Diffuse axonal injury patients’NSE levels were significantly higher （P 〈0.01）.Cisternal compressed,displacement〉5 mm serum NSE lev-els were significantly higher than the displacement 〈5 mm patients （P 〈0.01）;poor prognosis group’serum NSE lev-els were significantly higher than the good prognosis group （P 〈0.01 or P 〈0.05）;patients in death group NSE con-centration continued to increase.Conclusion Serum NSE concentrations was significantly associated with degree of Cis-ternal compression and displacement in Patients with Diffuse axonal injury,and can be used as a biomarker to assess not only the severity of acute traumatic brain injury,but also help determine prognosis.

关 键 词：弥漫性轴索损伤 CT NSE 

分 类 号：R651.1[医药卫生—外科学]