含氟纳米二氧化硅填料的制备及其氟释放性能研究  

Study on preparation and fluoride-release properties of fluorinated nanosilica filler

作　　者：王春风[1] 吴纲[1] 花曼曼[1] 高军[2] 殷恒波[2] 

机构地区：[1]解放军第三五九医院口腔科,镇江212006 [2]江苏大学化学化工学院,镇江212013

出　　处：《医学研究生学报》2015年第1期25-27,共3页Journal of Medical Postgraduates

基　　金：全军医学科学技术研究"十二五"发展计划项目(CWS11J264)

摘　　要：目的复合树脂是临床常用的牙体缺损修复材料,但对其释氟研究较少。文中研究评价纳米二氧化硅(Si O2)空心微球作为氟化钠(Na F)载体的可行性,测试载氟纳米Si O2空心微球在复合树脂中的氟释放特性。方法采用牺牲模板法制备纳米Si O2空心微球,采用浸渍法将Na F负载到空心微球内。扫描电镜观察微球载药前后的形态。按照Na F初始浓度为13.9,27.8、55.6 mg/m L在树脂中添加负载Na F的纳米Si O2空心微球和Na F粉末分别作为实验组和对照组。试件浸泡于37℃人工唾液中,分别于第1、2、5、8、13、19、26、33、47天后取样,测试各组试件氟释放累积量。结果扫描电镜观察牺牲模板法合成的Si O2空心微球呈现形态均一的球形结构。试件中Na F初始浓度为13.9、27.8、55.6 mg/m L时,2组第1、2、5、8、13、19、26、33、47天同时间氟释放累积量差异均有统计学意义(P<0.01)。结论纳米Si O2空心微球可作为Na F的载体,以负载Na F的纳米Si O2空心微球可作为填料。Objective The aim of the study was to develop a kind of new fluoride composite resin .We explored the practica-bility of preparing fluorinated filler by using hollow silica microsphere as a carrier of sodium fluoride （NaF） as well as its fluoride-re-lease properties in composite resin . Methods Hollow silica microspheres with mesoporous shells were prepared by the sacrificial template method.NaF was loaded into hollow silica microspheres by the impregnation method .Scanning electron microscopy （ SEM） was used to determine the morphologies of hollow silica microspheres before and after NaF loading .Hollow nanosilica microsphere con-taining NaF and NaF powder were respectively mixed with resin at the same intial NaF concentration of 13.9, 27.8 and 55.6 mg/mL for comparison, which were taken as the experiment group and the control group .The samples were put into 100 mL artificial saliva at 37℃to caculate the cumulative fluoride release quantities from 1 d to 47 d.Results The morphology of hollow microsphere did not chang significantly before and after NaF loading .In the experiment group ,the cumulative quantities of fluoride release were 0.026, 0.105, 0.21 mg/cm 2on 1 d and increased to 0.088, 0.239, 0.484 mg/cm 2on 47 d according to respective initial NaF concentration . While in the control group, the corresponding figures were 0.006, 0.025, 0.04 mg/cm2on 1 d and 0.022, 0.045, 0.056 mg/cm2on 47 d.The difference between these two groups was of great statistical significance . Conclusion Hollow silica microsphere could be used as a carrier of NaF .Fluorinated nanosilica filler using hollow microsphere promotes the fluoride release in composite resin .

关 键 词：二氧化硅空心微球 氟释放 复合树脂 

分 类 号：R34[医药卫生—基础医学]