Prognostic Significance of Tumor-infiltrating CD8^＋ or CD3^＋ T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer  

作　　者：Chuntao Tian Shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang Sun Liuxing Wang 

机构地区：[1]Department of Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China [2]Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China [3]Department of Oncology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China [4]Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China

出　　处：《Chinese Medical Journal》2015年第1期105-110,共6页中华医学杂志（英文版）

摘　　要：Background：Altered immunoresponse is associated with tumorigenesis and cancer progression.This study assessed the levels of tumor-infiltrating CD3^＋ or CD8^＋ T lymphocytes and interleukin-2 （IL-2） protein in radically resected non-small cell lung cancer （NSCLC） tissues to predict overall survival （OS） of the patients.Methods：Paraffin-embedded tissue specimens from 129 NSCLC patients were retrospectively collected for immunostaining of CD8^＋,CD3^＋,and IL-2 expression.Clinicopathological and survival data were collected and analyzed using the Chi-squared test,Kaplan-Meier curves,and the log-rank test or the Cox regression model.Results：The data showed a significant inverse association between CD8^＋ T lymphocyte levels and IL-2 expression （r =-0.927; P =0.000） and between the levels of CD8^＋ and CD3^＋ T lymphocytes （r =-0.722; P =0.000）,but a positive association between CD3^＋ T lymphocyte levels and IL-2 expression （r =0.781; P =0.000） in NSCLC tissues.Furthermore,the levels of CD3^＋ and CD8^＋ T lymphocytes and IL-2 expression were associated with tumor stage （P =0.023,0.006,and 0.031,respectively） and the level of CD8^＋ T lymphocytes was associated with the patient gender （P =0.024）.In addition,the levels of CD8^＋ T lymphocytes were associated with an unfavorable 5-year OS,whereas patients with high levels of CD3^＋ T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.Conclusions：The levels of CD8^＋ T cells in tumor lesions and IL-2 expression were both independent predictors of OS for these NSCLC patients.Thus,the detection of tumor-infiltrating CD3^＋ or CD8^＋ T lymphocytes and IL-2 expression could be useful to predict the prognosis of radically resected NSCLC patients.Background：Altered immunoresponse is associated with tumorigenesis and cancer progression.This study assessed the levels of tumor-infiltrating CD3^＋ or CD8^＋ T lymphocytes and interleukin-2 （IL-2） protein in radically resected non-small cell lung cancer （NSCLC） tissues to predict overall survival （OS） of the patients.Methods：Paraffin-embedded tissue specimens from 129 NSCLC patients were retrospectively collected for immunostaining of CD8^＋,CD3^＋,and IL-2 expression.Clinicopathological and survival data were collected and analyzed using the Chi-squared test,Kaplan-Meier curves,and the log-rank test or the Cox regression model.Results：The data showed a significant inverse association between CD8^＋ T lymphocyte levels and IL-2 expression （r =-0.927; P =0.000） and between the levels of CD8^＋ and CD3^＋ T lymphocytes （r =-0.722; P =0.000）,but a positive association between CD3^＋ T lymphocyte levels and IL-2 expression （r =0.781; P =0.000） in NSCLC tissues.Furthermore,the levels of CD3^＋ and CD8^＋ T lymphocytes and IL-2 expression were associated with tumor stage （P =0.023,0.006,and 0.031,respectively） and the level of CD8^＋ T lymphocytes was associated with the patient gender （P =0.024）.In addition,the levels of CD8^＋ T lymphocytes were associated with an unfavorable 5-year OS,whereas patients with high levels of CD3^＋ T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.Conclusions：The levels of CD8^＋ T cells in tumor lesions and IL-2 expression were both independent predictors of OS for these NSCLC patients.Thus,the detection of tumor-infiltrating CD3^＋ or CD8^＋ T lymphocytes and IL-2 expression could be useful to predict the prognosis of radically resected NSCLC patients.

关 键 词：IMMUNOHISTOCHEMISTRY Immunological Parameters Non-small Cell Lung Cancer Prognostic Factors 

分 类 号：S852.43[农业科学—基础兽医学] S852.4[农业科学—兽医学]