糖脂消对胰岛素抵抗高血压大鼠基因表达谱的影响  

The Influence of Tangzhixiao on Insulin Resisting Hypertension Rats' Gene Expression Profile

作　　者：王波[1] 李玉明[2] 赵旭燕[2] 蔡绍皙[3] 张延威[4] 

机构地区：[1]贵州师范学院实验教学管理中心,贵阳550018 [2]武警后勤学院平津医院心血管病研究所,天津300162 [3]重庆大学生物工程学院生物力学与组织工程教育部重点实验室,重庆400044 [4]贵州师范学院贵州省生物资源开发利用特色重点实验室,贵阳550018

出　　处：《价值工程》2014年第25期327-328,共2页Value Engineering

基　　金：贵州省教育厅"125"重大科技专项:黔教合重大专项字(2012)013号

摘　　要：目的:利用基因芯片技术探讨糖脂消对胰岛素抵抗高血压大鼠基因表达谱的变化,研究糖脂消治疗胰岛素抵抗高血压的作用机制。方法:用高果糖饲料诱发SD大鼠胰岛素抵抗模型,给予糖脂消口服后,用基因芯片分别检测高果糖组、治疗组,计算机软件分析后,观察基因表达的变化。结果:治疗组表达差异的基因有95条,新基因有23条,已知基因34条。结论:糖脂消可以改变其基因表达谱,为进一步探讨糖脂消治疗作用创造了条件。Objective： The gene chip technology is used to study the changes of Tangzhixiao on insulin resisting hypertensive rats＇ gene expression profile, and the mechanism of the effect of Tangzhixiao on Insulin Resisting Hypertension is studied. Methods： The high fructose diet is used to induce SD rats＇ insulin resistance model, and after giving the rats Tangzhixiao, the high fructose group and the treatment group are tested by the gene chip and the changes of gene expression is observed through the computer software analysis. Results： There are95 genes with differential expression, 23 new genes and 34 known genes in the treatment group. Conclusion： Tangzhixiao can change the gene expression profile, creating conditions for further exploring the treatment effect of Tangzhixiao.

关 键 词：糖脂消 基因芯片 胰岛素抵抗 基因表达谱 

分 类 号：R587[医药卫生—内分泌]