我国生物传感器研究现状及发展方向  

Research advances and development of biosensors in China

作　　者：史建国[1] 李一苇[1] 张先恩[2] 

机构地区：[1]山东省科学院生物研究所,山东省生物传感器重点实验室,山东济南250014 [2]中国科学院生物物理研究所,北京100101

出　　处：《山东科学》2015年第1期28-35,共8页Shandong Science

基　　金：国家高技术研究发展计划(863计划)(2012AA021201)

摘　　要：生物传感器是一个内容广泛、多学科介入和交叉的研究领域。本文以固定化酶传感器为重点,对我国生物传感器技术现状和特点进行了总结。在生物活性元件的种类、固定化策略和推广应用方面进行了分析,指出影响我国生物传感器实用化进程的主要问题是传感器酶品种缺乏、稳定性差以及检测底物范围受限等。以此为基础,在酶分子元件、生物电子器件、传感器制造技术及市场开发等几个方面,对今后发展重点和方向进行了探讨,建议加强新型酶分子元件、生物电子器件的标准化和分析系统的集成技术研究。Research on biosensors involves extensive contents, multiple disciplines and their overlap. We review its status quo and characteristics with emphasis on immobilizedenzyme sensors. We also address the kind of bioactive components, immobilization strategy andits applications. We further present the main issues affecting practical application process of Chinese biosensors-enzyme variety scarcity, bad stability and less analytical performance of instruments. We then explore its development emphasis and directions from enzyme molecular elements, bioelectronics components, manufacture technology and market development of biosensors. We eventually present our suggestions for the emphasis on the standardization of new enzyme molecular elements and bioelectronics components and integration technology of analytical system.

关 键 词：生物传感器 酶电极 分析仪器 应用市场 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]