高血压患者肺炎衣原体感染与颈动脉粥样硬化的相关性研究  

Correlation of Chlamydia pneumoniae infections and carotid atherosclerosis in patients with hypertension

作　　者：周代星[1] 严丽[1] 占成业[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院急诊科,湖北武汉430030

出　　处：《中华医院感染学杂志》2015年第4期791-793,共3页Chinese Journal of Nosocomiology

基　　金：湖北省自然科学基金资助项目(2013CFB080)

摘　　要：目的探讨高血压患者肺炎衣原体感染与颈动脉粥样硬化之间的相关性,以寻找有效治疗方法,认清高血压患者肺炎衣原体感染对颈动脉粥样硬化影响性,从而做好预防治疗措施,提高颈动脉粥样硬化临床诊治水平。方法选取2010年4月-2013年4月55例高血压肺炎衣原体感染患者为研究对象,作为观察组,另外选取同时期高血压非肺炎衣原体感染患者为对照组,比较两组患者在炎症指标、血脂水平等方面和颈动脉粥样硬化相关性。结果对照组患者颈动脉粥样硬化多发斑块、硬斑、软斑、混合斑的发生率分别为10.91%、9.09%、10.91%、5.45%,观察组分别为25.45%、20%、27.27%、21.82%,两组比较差异有统计学意义(P<0.05);两组患者血清总胆固醇、血清甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和炎症指标白细胞计数、C-反应蛋白、颈动脉内膜中层厚度、肿瘤坏死因子-α、白介素-1比较,差异均有统计学意义(P<0.05)。结论肺炎衣原体感染参与了颈动脉粥样硬化的病变发展过程。OBJECTIVE To investigate the correlation between Chlamydia pneumoniae infections and carotid atherosclerosis in patients with hypertension so as to find effective treatment methods,clarify the effect of C.pneumoniaeinfections in patients with hypertension on carotid atherosclerosis,thus to take prevention measures to improve clinical diagnosis and treatment of carotid atherosclerosis.METHODS Totally 55 hypertensive patients with C.pneumoniae infections during Apr.2010 to Apr.2013 were selected as the observation group for the study,and hypertensive patients with non-C.pneumoniae infections during the same period were selected as the control group.Patients of the two groups were compared for the correlation of inflammatory markers,lipids level with carotid atherosclerosis.RESULTS The incidences of multiple plaques,hard plaques,soft plaques,and mixed plaques of carotid atherosclerosis were 10.91%,9.09%,10.91%,5.45% in the control group and were25.45%,20%,27.27%,21.82% in the observation group.The difference was significant（P〈0.05）.The comparison of serum total cholesterol（TC）,serum triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）and inflammatory markers of white blood cell count,Creactive protein,IMT,tumor necrosis factor-α（TNF-α）,interleukin-1（IL-1）between the two groups showed significant differences（P〈0.05）.CONCLUSIONC.pneumoniae was involved in the pathological change of carotid atherosclerosis.

关 键 词：肺炎衣原体 感染 颈动脉粥样硬化 相关性 

分 类 号：R374[医药卫生—病原生物学]