口腔真菌感染患者口内假丝酵母菌属分布及药敏性分析  

Distribution of Candidain mouth and drug resistance testing of patients with oral fungal infections

作　　者：曾燕波 林红霞 叶智颖 郑海斌 

机构地区：[1]舟山市普陀区人民医院检验科,浙江舟山316100 [2]温岭市第一人民医院检验科,浙江温岭317500

出　　处：《中华医院感染学杂志》2015年第4期818-820,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅基金资助项目(2012KYA155)

摘　　要：目的了解口腔真菌感染患者口内假丝酵母菌属分布及药敏性,为临床治疗口腔真菌感染提供参考。方法选取2012年2月-2013年4月呼吸内科收治的82例口腔真菌感染患者,采集所有患者口腔黏膜标本,鉴定标本中的假丝酵母菌属菌种,并检测假丝酵母菌属对氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑和伏立康唑的药敏性。结果 82例患者送检标本中共培养出假丝酵母菌属103株,其中白色假丝酵母菌52株、热带假丝酵母菌21株、光滑假丝酵母菌13株,分别占50.5%、20.4%、12.6%;白色假丝酵母菌、热带假丝酵母菌和光滑假丝酵母菌对伏立康唑、两性霉素B的敏感率均为100.0%,其对氟胞嘧啶、氟康唑和伊曲康唑的敏感率分别为80.8%、94.2%、96.2%,85.7%、95.2%、100.0%和76.9%、100.0%、92.3%。结论口腔真菌感染可由多种菌株引起,因此临床中应明确假丝酵母菌属的菌种,并进行药敏试验,有利于选择有效的抗真菌药物,提高疗效。OBJECTIVE To understand the distribution of Candidain mouth and drug resistance in patients with oral fungal infections,so as to provide a reference for clinical treatment of oral fungal infections.METHODS Totally 82 patients with oral fungal infections in the department of respiratory medicine from Feb.2012 to Apr.2013 were selected.Oral mucosa specimens of all patients were collected to identify Candida species and drug resistance of Candida to flucytosine,amphotericin B,fluconazole,itraconazole and voriconazole were tested.RESULTS Totally 103 Candida bacteria were isolated in oral mucosa specimens of 82 patients,including 52 Candida albicans（50.5%）,21 C.tropicalis（20.4%）and 13 C.glabrata（12.6%）.Sensitive rates of C.albicans,C.tropicalis and C.glabrata to voriconazole,amphotericin B were all 100.0%,their sensitive rates to flucytosine,fluconazole and itraconazole were 80.8%,94.2%,96.2%;85.7%,95.2%,100.0%;and 76.9%,100.0%,92.3%.CONCLUSION Oral fungal infection can be caused by a variety of strains,therefore strains of Candidashould be clarified in clinical treatment,and drug sensitive test should be done,which is beneficial to choose effective antifungal drugs and improve curative effect.

关 键 词：口腔真菌感染 抗真菌药物 假丝酵母菌属 药敏试验 

分 类 号：R379[医药卫生—病原生物学]