吉妮柔适宫内节育器避孕效果的meta分析  

A meta-analysis for the contraceptive efficacy of GyneFix/soft intrauterine device

作　　者：干玎竹[1,2] 张文[1,2] 吴尚纯 

机构地区：[1]北京协和医学院研究生院,100730 [2]国家卫生计生委科学技术研究所

出　　处：《中国计划生育学杂志》2015年第2期81-86,共6页Chinese Journal of Family Planning

摘　　要：目的：比较分析吉妮柔适与其他常用宫内节育器（IuD）的避孕效果。方法：计算机检索CNKI（2008～2013）、CBMdisc（2008-2013）、万方（2008～2013）、维普（2008～2013），纳入吉妮柔适与其他常用IUD比较的随机对照试验（RCT）和临床对照试验（CCT），然后采用RevMan5．0软件进行meta分析。结果：共检索到177篇文献，根据纳入和排除标准，最终纳入5篇已发表研究。meta分析结果显示：①带器妊娠率与元宫Cu300IUD比较，吉妮柔适IUD在随访12、24个月时更低，差异有统计学意义（OR分别为O．06、0．09）。②脱落相关终止率与元宫Cu300IUD比较，吉妮柔适IUD在随访i2、24个月时更低，差异有统计学意义（OR分别为0．19、0．17）；与母体乐Cu375IUD比较，在随访i2、24个月时吉妮柔适IUD脱落率更低，差异有统计学意义（OR分别为o．22、O．22）。③吉妮柔适IUD在随访期间的因症取出率低于TCu380A和元宫Cu300IUD，差异有统计学意义。结论：现有证据表明，吉妮柔适IUD的带器妊娠率和脱落相关终止率均比较低，并且其无支架的设计能够有效降低因症取出率，具有良好的避孕效果。Objective： To compare the contraceptive efficacy of GyneFix/soft intrauterine device （IUD） with other com- monusing IUDs. Methods： We searched medical databases including CNKI （ 2008-2013）, CBMdisc （ 2008-2013 ）, Wanfang Database （2008-2013）, VIP Database （2008-2013） by computer. And we screened randomized control trials and then performed the meta-analysis by using RevManS.0 software. Results： Five articles from 177 literature were re cruited for meta-analysis according to the inclusion and exclusion criteria. The rate of pregnancy with IUD in situ of GyneFix/soft IUD was lower than that of Yuangong copper 300 IUD when followed up at 12, 24 months [Odd ratio （OR） were 0.06 and 0.09 respectively]. The expulsion rate of GyneFix/soft IUD was lower than that of Yuangong cop per 300 IUD when followed up at 12, 24 months （OR were 0.19 and 0.17 respectively）. The expulsion rate of GyneFix/soft 1UD was lower than that of multiload copper 375 IUD when followed up at 12, 24 months （OR were 0.22 and 0.22 respectively）. The removal rate for medical reasons of GyneFix/soft IUD was lower than those of cooper T380A IUD and Yuangong copper 300 1UD when followed up at 12, 24 months, and the differences were statistically significant. Conclusion： The rate of pregnancy with IUD in situ and the expulsion rate of GyneFix/soft IUD are low relatively. It has the favorable contraceptive efficacy and is worth using widely for less side effects and higher continuation rate.

关 键 词：META分析 吉妮柔适 宫内节育器 避孕效果 带器妊娠 

分 类 号：R169.4[医药卫生—公共卫生与预防医学]