临床药师干预清洁手术围术期预防应用抗菌药物的对比分析  

Comparative analysis of effects of preventive use of antibiotics in sterile surgery during perioperative period operated by clinical pharmacists

作　　者：吴琳 叶峥嵘[2] 卢健 仝敏 李艳 

机构地区：[1]咸阳市中心医院药剂科,陕西咸阳712000 [2]陕西中医学院病原生物及检验学教研室,陕西咸阳712046

出　　处：《中华医院感染学杂志》2015年第3期580-582,共3页Chinese Journal of Nosocomiology

基　　金：陕西省科技厅自然科学基金资助项目(2012JM4016)

摘　　要：目的评价临床药师干预清洁手术患者围手术期抗菌药物使用的效果,以提高合理用药水平。方法分别抽取医院2011年7-12月(干预前)和2012年7-12月(干预后)骨科清洁手术出院患者病历各150份,对围手术期预防性应用抗菌药物的合理性进行比较,采用Excel进行数据录入和处理,应用SPSS15.0软件进行统计分析。结果干预前有138例患者在围手术期预防性应用抗菌药物,经临床药师干预后,有70例患者预防性应用抗菌药物,抗菌药物使用率由92.00%降至46.67%,联合用药比例由7.25%降至0,品种选择合理率由23.91%升至97.14%,用药时机合理率由56.52%升至100.00%,用药疗程合理率由37.68%升至81.43%,总药品费用占住院总费用的比例由27.32%降至23.44%,抗菌药物总费用占总药品费用的比例由14.26%降至1.68%,患者人均住院天数下降1.25d。结论临床药师对围术期预防应用抗菌药物进行干预的方法是可行且有效,能提高医院抗菌药物的合理使用水平,减少患者的住院时间和住院费用,对临床安全、有效、经济的应用抗菌药物起到了积极作用。OBJECTIVE To estimate the effect of preventive use of antibiotics for patients in sterile surgery during perioperative period so as to improve the level of rational drug use. METHODS A total of 150 inpatients were collected from Jul. 2011 to Dec. 2011 as before intervention group and another 150 inpatients were collected from Jul. 2012 to Dec. 2012 as after intervention group, and then compared the rational use of antibiotics in perioperative period. The data were collected and processed by Excel. All data were analyzed by SPSS15. 0. RESULTS Totally 138 patients in the perioperative period took preventive use of antibiotics before intervention. After intervention by clinical pharmacists, the antibiotic usage rate of 70 patients was decreased from 92.00% to 46.67% % the combined medication rate declined from 7.25% to 0; the rate of rational variety choice was increased from 23.91% to 97.14%; the rate of rational administration drugs was went up from 56.52% to 100. 00%; the rate of rational course of treatment was improved from 37.68 % to 81.43 % the percentage of total hospitalization medicine expenses on the total hospitalization expense decreased from 27.32 % to 23.44% ; the percentage of total antibiotics expenses on total medicine expenses decreased from 14.26 % to 1.68 % ;and the average hospital stay of patients decreased by 1.25 days. CONCLUSIONS The preventive use of antibiotics in sterile surgery during perioperative period by the clinical pharmacists is feasible and effective, which could improve the level of rational antibiotic use and decrease hospital stay and expenses. It will also promote safe, effective and economical use of antibiotics.

关 键 词：临床药师 抗菌药物 清洁手术 干预 

分 类 号：R978.1[医药卫生—药品]