狼疮性肾炎患者医院感染的临床与病理特征研究  

Clinical and pathological studies in patients with lupus nephritis

作　　者：覃智慧[1] 刘珊[1] 谭德敏[1] 

机构地区：[1]湖北民族学院附属民大医院肾内科,湖北恩施445000

出　　处：《中华医院感染学杂志》2015年第3期621-622,652,共3页Chinese Journal of Nosocomiology

基　　金：湖北省科技厅科技基金资助项目(HK-2010A029)

摘　　要：目的探讨狼疮性肾炎患者医院感染临床与病理特征,以提高临床诊治水平。方法选取2010年4月-2013年4月135例狼疮性肾炎患者为研究对象,对其中发生医院感染的病例从感染部位、临床分型、临床病理特点和相关影响因素进行分析,数据采用SPSS16.0软件进行处理。结果 135例狼疮性肾炎患者医院感染57例,感染率42.22%;其中下呼吸道感染24例占42.1%;感染类型以急进型肾炎综合征、急性肾炎综合征感染率最高,分别为81.82%、61.54%;Ⅲ型感染率最高,为72.73%;其中易感因素有24h尿蛋白≥3.5g、血清白蛋白<30g/L、血肌酐升高、小管间质病变≥20%、激素应用时间长≥6个月、住院时间长≥60d、激素+环磷酰胺冲击治疗。结论狼疮性肾炎患者医院感染发生率较高,感染和狼疮临床活动、病理和治疗等各个方面均有相关性。OBJECTIVE To explore the clinical and pathological features in patients and improve the clinical diagnosis and treatment. METHODS A total of 135 patients with lupus nephritis from Apr. 2010 to Apr. 2013 were selected, and the infection sites, clinical types, pathological features and correlative factors were analyzed. All data were analyzed by SPSS16. 0. RESULTS Totally 135 cases of lupus nephritis complicated hospital-acquired infections heppened in 57 cases, with the infection rate of 42.22% ; among them 24 cases were lower respiratory tract infections （42. 1%）; in the type of infections, rapidly progressive nephritic syndrome, acute nephritic syndrome had the highest infection rate; Ill type had the highest infection rate for 72.73%; and the predisposing factors included 24 h urine protein ≥3. 5 g, hypoalbuminemia≥30 g/L, serum ereatinine, tubulointerstitial lesions ≥ 20%, hormone use for a long time ≥6 months, hospitalized for a long time ≥60 d, hormone＋CTX pulse therapy. CONCLUSION The incidence rate of nosoeomial infections in patients with lupus nephritis was high and the infection is associated with lupus clinical activity, pathology and treatment.

关 键 词：狼疮性肾炎 医院感染 病理特征 

分 类 号：R692.3[医药卫生—泌尿科学]