小儿推拿对哮喘患儿免疫功能的影响  

Effect of massage on immune function of children with asthma

作　　者：田福玲[1] 李旗[1] 崔建美[1] 马树祥[1] 王洪彬[1] 李雪青[1] 

机构地区：[1]河北联合大学中医学院,河北唐山063000

出　　处：《中国妇幼保健》2015年第5期710-713,共4页Maternal and Child Health Care of China

基　　金：国际科技合作计划项目〔2013DFG31080〕;国家自然基金项目〔81303046〕

摘　　要：目的:观察小儿推拿在小儿哮喘慢性持续期临床疗效和周围血T细胞和免疫蛋白变化情况。方法:将慢性持续期哮喘患儿120例,入选病例严格遵循随机分组原则分为试验组60例和对照组60例。对照组为常规雾化治疗,试验组在对照组治疗的基础上,应用小儿推拿,各观察3个月,在治疗前后观察哮喘临床症状,取外周血检测CD3+、CD4+、CD8+、CD4+CD25+、CD4+CD25+Foxp3+、转化生长因子-β1(TGF-β1)、免疫球蛋白A(Ig A)、免疫球蛋白E(Ig E)、免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)。结果:两组治疗后哮喘患儿活动受限、哮喘症状、心理情绪、对刺激原反应、自我关心较治疗前有明显提高,差异有统计学意义(P<0.05);治疗后试验组活动受限、哮喘症状、对刺激原反应、自我关心与对照组比较差异有统计学意义(P<0.05),试验组优于对照组。两组治疗后哮喘患儿周围血T细胞中CD3+、CD4+、CD8+、CD4+CD25+、CD4+CD25+Foxp3+、TGF-β1、Ig A、Ig G、Ig M较治疗前有明显提高,差异有统计学意义(P<0.05),治疗后试验组周围血T细胞中CD3+、CD4+、CD8+、CD4+CD25+、CD4+CD25+Foxp3+、TGF-β1、Ig A、Ig G、Ig E、Ig M与对照组比较差异有统计学意义(P<0.05),试验组优于对照组。结论:哮喘患儿可能通过小儿推拿有效地提高免疫功能,来改善其临床症状。Objective： To observe the clinical efficacy of massage for children with asthma during chronic persistent period and the changes of T lymphocytes and immune proteins in peripheral blood. Methods： A total of 120 children with asthma during chronic persistent period were selected and randomly divided into experimental group and control group, 60 children in each group. The children in control group were treated with traditional atomization inhalation treatment, while the children in experimental group were treated with atomization in- halation treatment combined with massage. All the children were observed for three months, clinical symptoms before and after treatment were observed in the two groups; peripheral blood specimens were obtained to detect CD3 ＋ , CD4 ＋ , CD8 ＋ , CD4 ＋ CD25 ＋ , CD4 ＋ CD25 ＋ Foxp3 ＋, transforming growth factor-β1（TGF- β1 ）, immunoglobulin A （IgA）, immunoglobulin E （IgE）, immunoglobulin G （IgG） and immunoglobulin M （IgM） levels. Results： In the two groups, limitation of motion, asthmatic symptoms, emotion, response to stimulators and self - concern after treatment were improved compared with before treatment （ P 〈 0.05 ） ; after treatment, there were statistically signifi- cant differences in limitation of motion, asthmatic symptoms, emotion, response to stimulators and self - concern between the two groups （ P 〈0.05）, experimental group was superior to control group; in the two groups, CD3＋ , CD4＋ , CD8＋ , CD4＋ CD25＋ , CD4＋ CD25＋ Foxp3 ＋ , TGF - β1, IgA, IgG, IgM levels in peripheral blood after treatment were improved compared with before treatment （ P 〈 0.05 ） ; after treatment, there were statistically significant differences in CD3 ＋ , CD4 ＋ , CD8 ＋ , CD4 ＋ CD25 ＋ , CD4＋ CD25 ＋ Foxp3 ＋ , TGF - β1, IgA, IgG, IgM levels between the two groups （P 〈0. 05）, experimental group was superior to control group. Conclusion： Massage can effectively improve clinical symptoms of children with as

关 键 词：哮喘 推拿 免疫 

分 类 号：R244.1[医药卫生—针灸推拿学] P562.25[医药卫生—中医临床基础]