吡唑并[3,4-d]嘧啶衍生物合成及其活性研究进展  

Research Progress of Synthesis and Pharmacological Activity of Pyrazolo [3,4-d] Pyrimidine Derivatives

作　　者：张美荣[1] 刘举[1] 张新威[1] 周云鹏[1] 陈烨[1] 王洋[1] 徐利锋[1] 

机构地区：[1]辽宁大学药学院,沈阳110036

出　　处：《中国药学杂志》2015年第3期194-200,共7页Chinese Pharmaceutical Journal

摘　　要：吡唑并[3,4-d]嘧啶衍生物药理作用的广泛性,引起了人们的高度重视。此类化合物在合成上,有多种途径,包括以吡唑环为母环、以嘧啶环为母环和以其他原料合成等;在药理活性上,能高效杀菌、消炎、抗凝血和抗癌等。笔者以合成方法为主线,对吡唑并[3,4-d]嘧啶衍生物的合成方法和药理活性研究进展进行了综述。Due to the extensive pharmacological effects, pyrazolo[ 3,4-d] pyrimidine derivatives have aroused great attention. There are a variety of ways in their synthesis, including using pyrazole ring, pyrimidine ring and other materials as parent ring. The compounds have strong bactericidal, anti-inflammatory, anti-cancer and anti-virus activities, etc. In this paper, the synthesis and pharmacological activities of pyrazolo[ 3,4-d] pyrimidine derivatives taking the synthesis as the main line are summarized.

关 键 词：吡唑并[3 4-d]嘧啶衍生物 合成 药理活性 

分 类 号：R96[医药卫生—药理学]