纳米粒子/聚合物复合光热平台的构筑和应用  

Construction of Nanoparticle/Polymer Composite Photothermal Nanoplatforms and Therapeutic Applications

作　　者：林敏[1] 王丹丹[2] 刘树威[1] 周鼎[1] 张皓[1] 刘畅[3] 孙宏晨[2] 

机构地区：[1]吉林大学超分子结构与材料国家重点实验室,长春130012 [2]吉林大学口腔医学院病理科,长春130021 [3]吉林大学口腔医学院口腔正畸科,长春130021

出　　处：《高分子学报》2015年第2期133-146,共14页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号21374042;21174051;21221063);吉林省自然科学基金(基金号201215030;20140101048JC);中央高校基本科研业务费专项资金;吉林大学研究生创新基金(基金号2014004)资助项目

摘　　要：叙述了一系列增强纳米粒子光热性能的方法,包括通过自组装方法调控纳米粒子的空间排列,进而优化电子结构和光热转化性能;在纳米粒子及其组装结构外表面进一步包覆具有光热性质的聚合物等.这些手段能够有效地增强光热试剂在近红外光区的消光能力,达到增强光热性能的目的.另外,包覆聚合物壳层后,纳米粒子的胶体稳定性、光稳定性以及生物兼容性都能得到进一步提高,为后续的体外细胞实验和动物体内肿瘤模型实验提供了可能.Nanoparticles （NPs） that are capable to convert near-infrared （NIR） irradiation into thermal energy have been demonstrated as the robust media for tumour curing. In this scenario, the photothermal performance of NPs greatly depends on their size, morphology, surface property, as well as the self-assembly architectures. Therefore,the practical applications of photothermal NPs in cancer therapy are determined by the technique progresses of nano-fabrications and multi-functional integration. In this scenario, the photothermal performance of NPs greatly depends on their size, morphology, surface property, as well as the self-assembly architectures. Therefore,the practical applications of photothermal NPs in cancer therapy are determined by the technique progresses of nano-fabrications and multi-functional integration. In this article,we summary a series of methods to enhance NP photothermal performance, such as control preparation of nanostructures, directing NPs self-assembly into specific architectures, and further photothermal polymer coating. The combination of these issues ensures the improvement of photothermal performance,colloidal and physiological stability, as well as biocompatibility.

关 键 词：光热治疗 纳米平台 自组装 纳米粒子 复合物 

分 类 号：TB383.1[一般工业技术—材料科学与工程]