基于基因表达水平和骨髓功能评估核辐射受照剂量的研究进展  

Progress of nuclear radiation dose based on gene express level and bone marrow function evaluation

作　　者：沈睿智 沈云天[1,2] 范秋虹[1,2] 田野[1,2] 刘增礼[1,2] 黄强[1,2] 

机构地区：[1]苏州大学附属第二医院 [2]中国核工业总医院,苏州215004

出　　处：《辐射研究与辐射工艺学报》2015年第1期6-12,共7页Journal of Radiation Research and Radiation Processing

基　　金：江苏省临床医学科技专项项目(BL2014040);苏州市科技发展计划指导项目(SYSD2013087)资助

摘　　要：在核事故中,超大剂量核辐射损伤的特点是瞬时发生和不可预测,在受辐射伤员的紧急救治过程中,其实际受照剂量往往是完全未知的,这给伤情的评估和针对性救治方案的制定带来了很大困难。针对这一现状,本文综合介绍了辐射敏感基因的应答性表达改变,可以用来评估伤员曾经接受到的辐射剂量;骨髓免疫显像可以动态评估伤员骨髓造血功能的建立情况;建立辐射致裸小鼠骨髓毁损后骨髓移植救治模型,可为伤员骨髓移植临床前研究奠定基础。In the nuclear accident, high doses of nuclear radiation may lead to instant and unpredictable injury. In the emergency treatment of radiation casualties, it is very difficult to assess the injury and carry out treatment programs because of the uncertainty of actual individual radiation dose. Therefore this article focuses on the progress of the following： radiation-sensitive gene expression changes can be used to evaluate the radiation dose of the wounded; bone marrow immune imaging can be used to dynamically assess the reconstruction of the bone marrow hematopoietic function; radiation damaged bone marrow of nude mice can be reconstructed by bone marrow transplantation, while this model can establish foundation for the preclinical study of casualties＇ bone marrow transplantation.

关 键 词：核辐射损伤 医疗救治 实验研究进展 

分 类 号：TL72[核科学技术—辐射防护及环境保护]