二氟沙星在乙腈溶液中的激光光解研究  

Laser flash photolysis studies on difloxacin in acetonitrile solution

作　　者：李海霞[1,2] 刘艳成[1,2] 唐睿智[1,2] 张鹏[1,2] 徐宇列[1,2] 王文锋[1] 

机构地区：[1]中国科学院上海应用物理研究所嘉定园区,上海201800 [2]中国科学院大学,北京100049

出　　处：《辐射研究与辐射工艺学报》2015年第1期39-45,共7页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金项目(21173252)资助

摘　　要：采用纳秒级激光光解瞬态研究技术,以乙腈作为溶剂,研究在355 nm激光作用下产生二氟沙星(DFX)激发三重态,并利用能量转移的实验进一步研究了二氟沙星激发三重态的性质。结果显示,萘普生和二氟沙星的二元体系在355 nm激光作用下,二氟沙星首先被激发为其激发三重态(580 nm),二氟沙星激发三重态与萘普生发生激发能转移,产生萘普生激发三重态(440 nm)。通过能量转移的方法确定了二氟沙星在乙腈溶剂中产生的激发三重态在最大吸收波长580 nm处的摩尔消光系数为8,900 dm3/mol·cm。通过改变二氟沙星的浓度测得其激发三重态在乙腈体系中的自衰变速率常数和三重态平均寿命(τ)分别为5.39×106 s-1和2.8μs。The photochemistry of difioxacin in acetonitrile was investigated using laser flash photolysis. Energy transfer method was also used to estimate the properties of the triplet state of difloxacin. The results showed that excitation of the solution containing difloxacin and naproxen upon 355 nm laser flash produced the triplet of difloxacin at 580 nm firstly. Subsequently, the excitation energy of triplet difloxacin was transferred to naproxen generating triplet naproxen. Characteristic absorption of the triplet state of naproxen at 440 nm was recorded. By means of transfer of excitation energy, the molar absorption coefficients of triplet difloxacin were determined to be 8,900 dm3/mol·cm at 580 nm. Through changing the concentration of difloxacin, the self-decay rate constant and triplet lifetime for difloxacin in acetonitrile solution were observed to be 5.39×10^6S^-1and 2.8 μs.

关 键 词：激光光解 激发态三重态 二氟沙星 萘普生 

分 类 号：TL13[核科学技术—核能科学]