川芎嗪抗组织粘连研究进展  

Review on Anti-adhesion Activity of Tetramethylpyrazine

作　　者：颜帅[1] 李文林[1] 曾莉[1] 

机构地区：[1]南京中医药大学,南京210023

出　　处：《天然产物研究与开发》2015年第2期367-371,共5页Natural Product Research and Development

基　　金：国家自然科学基金(81373843);江苏省普通高校研究生科研创新计划(CXZZ13_0613);南京中医药大学中医学一级学科开放课题(YS2012ZYX111);江苏省中医药局科技项目(LZ13006)

摘　　要：对近年来川芎嗪抗组织粘连的作用,为临床研究和研发新药提供参考。结果发现,川芎嗪可通过抑制胶原增生过度、与粘连相关的因子过度表达、降低血浆中白细胞和纤维蛋白的浓度等多靶点、多环节发挥抗粘连作用。但是研究多集中在体外实验及动物实验,亟需进一步从临床研究上证实其抗粘连作用,未来基础研究应集中在川芎嗪生物材料的研发。Recent studies of antl-adhesion mechanism of tetramethylpyrazlne were reviewed to provide reference for clini- cal study and new drug development. It was found that the anti-adhesion mechanism of tetramethylpyrazine involved multi-targets and multi-llnks such as the inhibition of proliferation of collagen, over-expression of adhesion related fac- tors, and reduction of the concentration of white blood cells and fibrin in plasma. In future, more clinical evidence was still required, and the basic research of tetramethylpyrazine should be focused on the biomaterial development.

关 键 词：川芎嗪 粘连 药理作用 

分 类 号：R264[医药卫生—中医外科学]