血型不规则抗体筛查用于预防和降低临床无效输血的发生  

The application of irregular antibody screening in the prevention and reduction of invalid clinical transfusion

作　　者：赵颖欣[1] 王德辉[1] 柴慧丽[1] 于莹[1] 佟欣[1] 靳艳华[1] 

机构地区：[1]哈尔滨市第一医院输血科,黑龙江哈尔滨150010

出　　处：《中国输血杂志》2015年第1期48-50,共3页Chinese Journal of Blood Transfusion

摘　　要：目的预防或/和降低临床无效输血的发生。方法评估本院2011年6月-2012年1月的1 500名患者的输血效果,对其中发生输血无效的患者,应用增强检测方法:降低抗体筛查细胞浓度,增加待检血清与抗体筛查细胞比例,应用增强剂,增加抗球蛋白法孵育时间,采用吸收/放散法检测作红细胞血型不规则抗体鉴定检测。结果未作血型不规则抗体筛查鉴定前,本院的输血无效率为9.80%(147/500);经血型不规则抗体鉴定检测,147名输血无效患者中有37人的血清中检测到不规则抗体,其中17名患者再次输血时给与相配合的红细胞输注,未发生无效输血。结论血型不规则抗体的筛查和鉴定有助于预防和降低红细胞输注无效。Objective To prevent and/or to reduce the occurrence of invalid clinical transfusion. Methods Blood transfusion efficacy in 1 500 patients between June 2011 and January 2012 in our hospital was assessed. Among the patients who had received invalid transfusion, the following detection methods were enhanced ： the concentration of antibody screening cells was reduced ; the ratio of serum and antibody screening cells was increased; a stronger detection agent was applied ; the incubation time of anti globulin was raised; absorptive radiation method was used to screen on irregular antibodies in red blood cells. Results From June 2011 to January 2012, before any identification of irregular antibody during blood screen- ing, blood transfusion inefficacy was 9.80% （ 147/500 ）. After the identification of irregular antibody by detecting blood types, irregular antibodies were detected in the serum of 37 patients, out of 147 who had received invalid clinical transfu- sion. Among these 147 patients, 17 received compatible blood transfusion and had not experienced transfusion inefficacy. Conclusion Irregular antibody screening and identification of blood types can help prevent and reduce the invalid transfu- sion of red blood cells.

关 键 词：不规则抗体筛查 红细胞血型 无效输血 输血疗效评估 预防 

分 类 号：R457.11[医药卫生—治疗学]