我中心干预前后静脉注射盐酸左氧氟沙星致不良反应报告分析  

Analysis of ADR Induced by Intravenous Injection of Levofloxacine Hydrochloride before and after Intervention

作　　者：鄢春红 

机构地区：[1]宁波市海曙区西门望春社区卫生服务中心,浙江宁波315016

出　　处：《中国药房》2015年第5期636-638,共3页China Pharmacy

摘　　要：目的:评价我中心采取干预措施的有效性,促进临床合理使用抗菌药物。方法:随机选取2013年1-6月(干预前)和2013年7-12月(干预后)门诊静脉使用盐酸左氧氟沙星注射液抗感染治疗的患者,排除有基础疾病或过敏体质者后,均为2 272例。对其中发生的不良反应(ADR)进行统计、分析。结果:36例ADR报告中,干预前24例(1.06%),干预后12例(0.53%),干预前后ADR发生率差异有统计学意义(P<0.05)。65岁以上老年患者ADR发生率最高,共有16例(44.44%);女性患者25例(69.44%),显著高于男性患者(11例,30.56%);患者用药后1 h内发生的ADR例数最多,共有17例(47.22%);ADR的临床表现以皮肤及其附件损害最多,共有17例(29.31%)。结论:干预措施成效显著,ADR发生率有效降低。OBJECTIVE ： To evaluated the validity of regulatory measures in our center, and promote rational use of antimi- crobial drugs. METHODS： The patients receiving anti-infection therapy of Levofloxacine hydrochloride injection were randomly selected from outpatient department before intervention （Jan.-Jun. 2013） and after intervention （Jul.-Dec. 2013）, while those with basic diseases or allergic constitution were excluded. 2 272 cases and 2 272 cases were selected respectively. Adverse drug reaction （ADR） was analyzed statistically. RESULTS： Among 36 cases of ADR, 24 cases occurred before intervention （1.06%） and 12 occurred after intervention （0.53%） ; there was statistically significant difference in the incidence of ADR before and after intervention （P〈0.05）. The patients aged over 65 took up the highest proportion in the incidence of ADR （16 cases, 44.44% ） there were 25 female patients （69.44%）, which was significantly higher than the number of male patients （11 cases, 30.56% ）. The number of ADR occurred with 7 h after medication was the most （17 cases, 47.22% ）; the most common ADR was lesion of skin and its appenden ts （17 cases, 29.13 % ）. CONCLUSIONS： The interventions are remarkable and the incidence of ADR is effectively reduced.

关 键 词：盐酸左氧氟沙星注射液 不良反应 干预 分析 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]