临床药师对癌痛治疗不合理用药的干预效果  

Effects of Cancer Pain Irrational Drug Use from the Intervention of Clinical Pharmacists

作　　者：魏妙华[1] 吴春美[1] 张利平[1] 王双虎[1] 

机构地区：[1]丽水市人民医院临床药学科,浙江丽水323000

出　　处：《中国药房》2015年第5期683-685,共3页China Pharmacy

基　　金：浙江省医学会临床科研基金项目(No.2012ZYCA113)

摘　　要：目的:优化癌痛药物治疗,提高癌痛控制水平。方法:选取我院肿瘤科2011年7-12月(干预前)151例及2013年7-12月(干预后)146例癌痛患者的出院病历,对癌痛治疗药物的使用合理性进行对比分析。结果:临床药师干预后镇痛药物使用逐步规范,用药合理率由47.68%上升至85.62%(χ2=47.828,P=0.000<0.01);镇痛药治疗24 h、3 d的疼痛缓解率分别为68.49%、92.47%,明显高于干预前的43.05%、67.55%(P<0.01);干预后便秘和恶心呕吐的不良反应发生率降低(P<0.05),患者用药依从性提高(P<0.01)。结论:临床药师采取的干预措施有效可行,对促进临床合理使用镇痛药物,规范癌痛治疗起到积极作用。OBJECTIVE： To provide reference for rational use of analgesic agents and standard treatment of cancer pain. METHODS： The medical records of 151 discharged patients with cancer pain were collected from oncology department of our hospital during Jul.-Dec. 2011 （before intervention） and those of 146 patients collected during Jul.-Dec. 2013 （after intervention）. The rationality of drugs used in cancer pain treatment was analyzed comparatively. RESULTS： After clinical pharmacist＇s intervention, the use of analgesic drugs became standard gradually, and reasonable rate of drug use raised to 85.62% from 47.68% （X^2=47.828, P=0.000（0.01） ; the rate of pain relief was 68.49% after 24 h analgesic drug therapy and 92.47% after 3 d analgesic drug thera- py, which were both higher than 43.05% and 67.55% and 90.07% before intervention （P〈0.01）; the incidence of ADR as constipation, nausea and vomiting decreased （P（0.05）, and the compliance of patients increased （P〈0.01） after intervention. CONCLUSIONS： The intervention measures by clinical pharmacists are effective and feasible, and play positive role in promoting the rational use of analgesic drugs and standardizing the treatment of cancer pain.

关 键 词：临床药师 癌痛 合理用药 干预 

分 类 号：R95[医药卫生—药学] R969.3