临床药师干预前后苄星青霉素致严重不良反应的实例分析  

Analysis of the Effects of Clinical Pharmacists' Intervention on Benzathine Benzylpenicillin-induced Serious ADR in Syphilis Patients

作　　者：宁俊凯[1] 陈清[1] 陈巧辉[1] 杨昌云[1] 

机构地区：[1]解放军第180医院,福建泉州362000

出　　处：《中国药房》2015年第5期699-701,共3页China Pharmacy

摘　　要：目的:探讨临床药师参与药品不良反应(ADR)监测及干预的效果。方法:分析2012年11月-2013年4月我院门诊上报的11例早期梅毒患者肌肉注射苄星青霉素后引起过敏性休克严重ADR的报告,按照临床药师干预前后进行分组。干预措施包括严格规范青霉素皮试液的配制、关注药品生产批号并及时上报和更换不同批号药品、严格按药品说明书用药。比较干预前后的严重ADR发生率及患者的治愈效果。结果:经临床药师干预后,半年内我院门诊注射用苄星青霉素引起严重ADR的发生率呈明显下降趋势;干预前后患者的临床治愈率均良好(100%)(P>0.05),血清学转阴率分别为66.49%、60.00%(P>0.05)。结论:临床药师实施ADR监测,及时干预治疗,可明显降低ADR的发生率。OBJECTIVE： To investigate the effects of clinical pharmacists participating in ADR monitoring and intervention. METHODS： Serious ADR reports about allergic shock in 11 early syphilis patients after intramuscular injection of benzathine benzylpenicillin reported by outpatient department of our hospital during Nov. 2012-Apr. 2013 were analyzed and grouped according to clinical pharmacists＇ intervention. Intervention measures included strictly standardizing the preparation of skin test solution, focus- ing on batch number, reporting and replacing different batch number of drugs timely, using drugs strictly in accordance to package inserts. The incidence of serious ADR and cure effect were compared before and after intervention. RESULTS： After clinical phar- macists＇ intervention, the incidence of benzathine benzylpenicillin-induced serious ADR decreased significantly in outpatient department of our hospital in half year. And the cure rate of patients was fine in 2 groups before and after intervention （100%） （P〉 0.05）, and negative conversion rates of serology were 66.49% and 60.00% （P〉0.05）. CONCLUSIONS： The ADR monitoring of clinical pharmacist and timely intervention could significantly reduce the occurrence of ADR.

关 键 词：临床药师 干预 苄星青霉素 严重不良反应 分析 

分 类 号：R95[医药卫生—药学] R759.1