丹红注射液对不稳定型心绞痛患者血清hs-CRP、GDF-15的影响  

Clinical Study of Danhong Injection for Treating52 Cases with Unstable Angina

作　　者：刘红霞[1] 殷春萍[1] 王长垠[1] 宋蕾[1] 

机构地区：[1]邯郸市中医院,河北邯郸056001

出　　处：《河南中医》2015年第1期63-64,共2页Henan Traditional Chinese Medicine

摘　　要：目的:观察丹红注射液对不稳定型心绞痛血清hs-CRP、GDF-15的影响。方法:将104例不稳定型心绞痛患者随机分为对照组和治疗组各52例,对照组患者给予常规治疗,包括抗血小板、硝酸酯类、β-受体阻滞剂、钙拮抗剂等药物,合并高血压、糖尿病的患者分别给予药物治疗,治疗组在对照组基础上加用丹红注射液30 m L,加入0.9%的氯化钠250 m L中静脉滴注,日1次,均以2周为1个疗程。结果:对照组有效率为73.08%,治疗组有效率为88.46%,两组有效率比较,差异有显著性(P<0.05);治疗后两组血清hs-CRP、GDF-15含量均有下调,与本组治疗前比较差异均有统计学意义(P均<0.01),治疗组较对照组下调更为明显(P均<0.05)。结论:丹红注射液可以显著提高UAP的临床疗效,减少心绞痛的发作次数,并且可以显著降低血清hs-CRP、GDF-15的表达水平。Objective： To observe the clinical effects of Danhong Injection on unstable angina. Methods： 104 cases with unstable angina were randomized into control group and treatment group,52 cases in each group. The control group were given conventional treatment; the treatment group were given Danhong Injection in addition to the above conventional treatment,2 weeks as a treatment course for both groups. The efficacy was determined after one course. Results： The effective rate of the control group was 73. 08% while that of the treatment group was 88. 46%. By comparison,the difference was significant（ P〈0. 05）. The contents of hs-CRP and GDF-15 in the serum of both groups declined. There was statistical significance when comparison was made with the contents before the treatment（ P〈0. 01）. The decline in the treatment group was more obvious than that in the control group（ P〈0. 01）. Conclusion： Danhong Injection can greatly improve the clinical effects on unstable angina,reduce the occurrence of angina,and significantly decrease the expression level of hs-CRP and GDF-15 in the serum.

关 键 词：不稳定型心绞痛 丹红注射液 超敏C反应蛋白 生长分化因子15 

分 类 号：R256.22[医药卫生—中医内科学]