颈动脉粥样硬化患者臂踝脉搏波传导速度baPWV与颈动脉内中膜厚度IMT相关性研究  

The Correlation Research on Ba PWV and IMT of Patients with Carotid Atherosclerosis

作　　者：程蓉岐[1] 沈睿[1] 陈川[2] 申定珠[2] 楼丹飞[1] 李越华[1] 粟文娟[1] 贾春岩[1] 

机构地区：[1]上海市中医医院,上海200071 [2]上海市中医老年医学研究所,上海200031

出　　处：《河南中医》2015年第1期102-103,共2页Henan Traditional Chinese Medicine

基　　金：上海市卫生局局级科研项目(编号:2010225;20114047);上海市卫生局中医药科研基金项目(编号:2010L046A);上海市教委预算内科研项目(编号:2011JW50;2012JW59)

摘　　要：目的:通过联合运用多普勒超声与动脉硬化仪探讨颈动脉粥样硬化患者颈动脉内中膜厚度(IMT)与臂踝脉搏波传导速度(ba PWV)的相关性,综合评价补肾中药复方首参颗粒的临床疗效。方法:选取156例颈动脉粥样硬化患者,随机分为西药组73例和中药组83例,西药组口服普法他汀治疗,中药组服用首参颗粒治疗,疗程均为6个月。分析颈动脉粥样硬化患者ba PWV与IMT的相关性,观察两组患者治疗前、治疗后IMT与ba PWV变化。结果:156例颈动脉粥样硬化患者IMT与ba PWV之间呈显著正相关(相关系数为0.1873),两组治疗后IMT与ba PWV均较治疗前明显降低(P<0.01或P<0.05),两组间同期比较差异无统计学意义(P>0.05)。结论:IMT与ba PWV可作为颈动脉粥样硬化患者临床监测的有效指标,首参颗粒可能通过降低颈动脉粥样硬化患者IMT、ba PWV进而有效干预动脉粥样硬化。Objective： To explore the correlation between ba PWV and IMT of patients with carotid atherosclerosis through combined use of Doppler ultrasound technique and atherosclerosis instrument,and comprehensively judge the clinical effect of Compound Tablets of head Renshen for tonifying kidney. Methods： 156 patients with carotid atherosclerosis were randomly divided into the Western medicine group and Chinese medicine group,with 73 cases and 83 in each group respectively. The patients in the Western medicine group were treated with pravastatin,while the ones in the Chinese medicine group were given head Renshen particle,and both of their treatment course lasted 6 months. Then the correlation between ba PWV and IMT was analyzed,and changes of IMT and ba PWV before and after the treatment were observed. Results： Among these 156 patients with carotid atherosclerosis,there was positive correlation with 0. 1873 correlation quotient between IMT and ba PWV. IMT and ba PWV after the treatment were obviously lower than those before the treatment（ P〈0. 01 or P〈0. 05）. And there was no statistical meaning between the two groups simultaneously（ P〉0. 05）. Conclusion： IMT and ba PWV can be regarded as effective indexes to test clinically patients with carotid atherosclerosis; Head Renshen particle can effectively interfere carotid atherosclerosis through reducing patients＇ IMT and ba PWV.

关 键 词：颈动脉粥样硬化 IMT ba PWV 首参颗粒 普法他汀 

分 类 号：R259.435[医药卫生—中西医结合]