围生期心肌病的研究进展  

Progress in Research on Peripartum Cardiomyopathy

作　　者：杜贺[1] 史承勇[1] 陈少萍[1] 

机构地区：[1]第二军医大学长海医院心血管内科,上海200090

出　　处：《心血管病学进展》2015年第1期30-33,共4页Advances in Cardiovascular Diseases

摘　　要：围生期心肌病是指在妊娠晚期和产后早期出现左心室收缩功能障碍和心力衰竭等症状为表现的紊乱综合征。其发病率随地域不同有很大差异,一些地区很常见而有些地区比较少见。新的研究揭示围生期心肌病可能是多因素引起的疾病。基于氧化应激反应,导致催乳素裂解为有害的相对分子质量16 000形式,这种裂解可以被溴隐亭阻断。围生期心肌病诊断易被延迟且具有高的发病率和病死率。现就围生期心肌病的病因、诊断、药物治疗和孕期管理等方面的进展进行综述。Peripartum cardiomyopathy（ PPCM） is a disorder in which initial left ventricular systolic dysfunction and symptoms of heart failure occur between the late stages of pregnancy and the early post partum period. Incidences vary geographically; it is common in some countries and rare in others. New investigations reveal that PPCM is likely due to multiple factors. It develops based on oxidative stress leading to cleavage of deleterious 1. 6 × 104 k D aprolactin,which can be blocked with bromocriptine. The syndrome carries a high morbidity and mortality and diagnosis is often delayed. This review focuses on new data and aspects in terms of diagnosis,causes of disease,pharmacological therapy,and management of delivery in patients with PPCM.

关 键 词：心力衰竭 围生期心肌病 妊娠 

分 类 号：R714.25[医药卫生—妇产科学]