安庆农村地区男性吸烟与认知功能的相关性分析  

Evaluation for the association of smoking with cognitive function in Anqing rural male population

作　　者：崔伟[1] 罗静[1] 丁昱[1] 蒋善群[2] 郑美丽[3] 汪凯[4] 谢海群[5] 秦献辉[1] 唐根富[1] 王滨燕[1] 臧桐华[1] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032 [2]安徽大学生命科学学院,安徽合肥230061 [3]首都医科大学附属北京朝阳医院心内科,北京100016 [4]安徽医科大学第一附属医院神经内科,安徽合肥230022 [5]佛山市第一人民医院,广东佛山528000

出　　处：《中华疾病控制杂志》2015年第2期150-153,共4页Chinese Journal of Disease Control & Prevention

摘　　要：目的 探讨安庆农村地区男性人群吸烟状态与认知功能的关系及其影响因素。方法 研究对象来自2013年8月6日～24日在安庆地区农村人群中进行的流行病学调查。通过问卷收集受试者简易精神状态（mini-mental state examination,MMSE）评分、吸烟信息和其他相关变量,采用多元线性回归模型评估吸烟与MMSE评分的关联。结果 615例男性受试者纳入最终分析。调整年龄、教育程度、血压、体质指数、生活习惯、饮酒、卒中史和抑郁评分后,与从不吸烟者（24.4±5.0）相比,吸烟者（以前或现在吸烟者）（24.8±4.7）（β=0.72,sx=0.35,P=0.038）MMSE评分增加。在文盲人群,以前吸烟（22.3±4.6）（β=1.62,sx=0.83,P=0.05）和现在吸烟者（21.9±4.8）（β=1.36,sx珋=0.68,P=0.046）与从不吸烟者（20.8±4.8）相比,MMSE评分明显增加;而在不同年龄分层,二者未见明显差异。结论 吸烟与MMSE评分呈显著正相关,且在文盲人群中更为明显。Objective To investigate the association between smoking status and cognitive function as well as the influencing factors in Anqing rural male participants. Methods Study participants were from an epidemiological survey conducted from August 6 to 24th, 2013 in Anqing rural area. MMSE scores, smoking status and other relevant information were ascertained by trained research staff according to standard operating procedures. The relationship of smoking and MMSE scores was evaluated using multiple linear regression models with adjustment for age, education levels, body mass index, living habits, history of stroke and depression. Results In this study, 615 male participants were included in the final analysis. Compared with non-smokers （ MMSE scores ： 24. 4 ± 5. 0） , smokers （ current or ever smoking, 24. 8 ± 4. 7） had significantly higher MMSE scores （ 13 = 0. 72, sx = 0. 35,P = 0. 038）. Furthermore, the higher MMSE scores in both ever （22. 3 ±4. 6 versus 20. 8 ± 4. 8 （non-smokers） , β = 1.62 ,sx = 0. 83 ,P = 0. 050） and current smokers （21.9 ± 4. 8 versus （non-smokers） , β = 1.36 ,sx =0. 68 ,P =0. 046） were mainly observed in illiterate participants. Age did not signifi- cantly modify the association between smoking status and MMSE scores. Conclusions Cigarette smoking is significantly associated with increased cognitive function, particularly in illiterate population.

关 键 词：吸烟 认知 流行病学方法 教育程度 

分 类 号：R181.22[医药卫生—流行病学]