对动物饲料中禁用抗菌促生长剂的反思  

Rethinking the Withdrawal of Antimicrobial Growth Promotants in Animal Feed

作　　者：郝海红[1] 程古月[1] 戴梦红[1] 王旭[1] 王玉莲[1] 黄玲利[1] 刘振利[1] 袁宗辉[1] 

机构地区：[1]华中农业大学/国家兽药残留基准实验室(华中农业大学)/农业部畜禽产品质量安全风险评估实验室(武汉),武汉430070

出　　处：《中国农业科学》2015年第3期594-603,共10页Scientia Agricultura Sinica

基　　金：国家自然科学基金(31101856);国家科技支撑计划(2012BAK01B02);教育部博士点新教师基金(2011014612003)

摘　　要：欧盟国家对饲用抗菌促生长剂禁令的颁布引起了国际社会的广泛争议。文章综合动物源细菌耐药性监测数据和风险评估结果,对饲料中禁用抗菌促生长剂进行了反思,结果发现:(1)某些饲用抗菌促生长剂(如大环内酯类促生长剂泰乐菌素和链阳性菌素类促生长剂维吉尼亚霉素等)对人类健康的耐药性风险似乎被人为夸大,系统的风险评估结论认为,养殖动物中泰乐菌素等大环内酯类促生长剂的使用对人类弯曲杆菌耐药性的风险是可以忽略的,维吉尼亚霉素促生长剂的应用也几乎不会对人类肠球菌耐药性造成很大的风险;(2)"病原菌耐药性从农场到餐桌转移"的命题似乎缺乏科学证据,目前虽然有证据显示动物体耐药菌会直接传播给那些与动物密切接触的人群,但动物体耐药菌通过食物链环节传播给人的证据尚不充分;(3)禁用抗菌促生长剂并没有改变耐药模式,特别是禁用糖肽类阿伏帕星、氟喹诺酮类恩诺沙星和四环素类金霉素等促生长剂后,动物体和人体耐药菌数量仍然有增无减、持续上升,其原因可能归咎于万古霉素耐药屎肠球菌较强的传播特性和氟喹诺酮类耐药弯曲杆菌较强的适应性,而四环素类治疗用药的增加也必然增加肠道细菌的耐药性;(4)禁用抗菌促生长剂对动物养殖业带了一定的损失,比如,使产气荚膜梭菌引起的坏死性肠炎的发病率升高,使养殖动物治疗性抗生素的使用量增加,使养殖原料和场地相应增加等;(5)禁用抗菌促生长剂对动物源性食品安全和人类公共健康造成了一定的影响,比如,影响动物体肠道菌群发酵从而增加了有害气体的排放,提高了食品加工过程中的细菌污染几率从而增加了人体食源性病原菌的发病率。总而言之,决策的制定需要权衡利弊、因地因时制宜,综合考虑禁用抗菌促生长剂对耐药性风险的控制作用以及对动物养殖业和人Withdrawal of antimicrobial growth promotants（AGPs） in animal feed issued by European Union（EU） countries caused widespread controversy in the international community. This paper comprehensively reviewed the antimicrobial resistance monitoring data from animal original bacteria and the risk assessment results of veterinary usage. After profoundly rethinking the ban of AGPs in animal feed, the results showed that（1） the risk of some AGPs（e.g. macrolide AGP of tylosin and streptogramin AGP of virginiamycin） seemed to be overstated. The risk of the usage of macrolide AGPs in food animals to emergence of macrolide resistant Campylobacter in human is negligible, and the use of virginiamycin as AGPs could hardly affect the treatment of humaninfections caused by Enterococcus;（2）There is a lack of scientific evidence for supporting the proposition of transmission of antimicrobial resistance from farm to dining table. Although there are some evidence that antimicrobial resistant bacteria could directly transmit from food animal to those persons who closely contacted with animals, there is no direct and sufficient evidents to support the transfer of antimicrobial resistant pathogens through food chain to persons;（3） Withdrawal of AGPs did not change the epidemiology of resistant pathogens, especially for the avoparcin in glycopeptides, enrofloxacin in fluoroquinolones and chlorotetracycline in tetracyclines. After ban of these three classes of AGPs, the number of resistant bacteria from both animal and human continued to increase. The reason may be attributed to the enhanced fitness of fluoroquinolone resistance in Campylobacter and the increase of the consumption of therapeutic tetracycline agents;（4） Withdrawal of the AGPs may brought a certain loss for the animal breeding industry. For example, it may increase the incidence of necrotizing enteritis caused by Clostridium, increase therapeutic use of antimicrobial agents in the farmed animals, and increase breeding materials and corresponding v

关 键 词：动物饲料 抗菌促生长剂 禁用 耐药性风险 合理用药 

分 类 号：S816[农业科学—饲料科学] S859.8[农业科学—畜牧学]