含D-乙酰氨基葡萄糖的酰氨基硫脲合成及表征  

Synthesis and Characterization of Acylthiosemicarbazides Containing D-Acetylglucosamine

作　　者：李曲祥 刘玮炜[1,2,3] 程峰昌 张强[1] 霍云峰[2] 

机构地区：[1]中国矿业大学化工学院,江苏徐州221116 [2]淮海工学院化学工程学院,江苏连云港222005 [3]江苏省海洋资源开发研究院,江苏连云港222005

出　　处：《化学试剂》2015年第2期117-121,共5页Chemical Reagents

基　　金：江苏省高校自然科学研究重大基金资助项目(10KJA170003);连云港市科技攻关基金资助项目(CG1105);江苏省高校科研成果产业化推进项目(JHB2012-60)

摘　　要：以D-氨基葡萄糖盐酸盐为起始原料,经过酰化、氯代和异硫氰酸酯化制得中间体2-乙酰氨基-3,4,6-三-O-乙酰基-2-脱氧-β-D-吡喃糖基异硫氰酸酯,再与各种酰肼反应,得到了12种新型的标题化合物。产物结构均经IR、1HNMR和ESI-MS确认。所得糖基衍生物构型未发生变化,均为β型。2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl isothiocyanate was synthesized through following steps,acylation,chlorination and isothiocyanate with D-glucosamine hydrochloride as starting material. The reaction of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl isothiocyanate with various hydrazides obtained 12 novel title compounds. The structures were confirmed by IR,1HNMR and ESI-MS,and the all glycosyl derivatives kept the original β-configuration.

关 键 词：D-氨基葡萄糖 酰氨基硫脲 异硫氰酸酯 合成 

分 类 号：O629.11[理学—有机化学]