达泊西汀的合成  

Synthesis of Dapoxetine

作　　者：宁岩实 林长江[2] 陆志进 郑云松[2] 李福华[2] 

机构地区：[1]国际关系学院,北京100091 [2]北京微量化学研究所,北京100091

出　　处：《化学试剂》2015年第2期185-188,共4页Chemical Reagents

摘　　要：以手性原料D-苯甘氨酸为起始原料,经8步反应合成了标题化合物。利用1HNMR、13CNMR、质谱及比旋光度确认其化学结构,总收率达到30.4%。该方法原料易得、操作简单、收率高,不需要进行手性拆分,适合工业化生产。To synthesize dapoxetine,a compound serotonin re-uptake inhibitor. Dapoxetine was synthesized from D-Phenylglycine via eight steps. The chemical structure of the target compound was confirmed by1 HNMR,13CNMR and MS. The total yield was30. 4%. This synthesis is an easily manipulated synthetic process with high yield and it is also suited of industrialization.

关 键 词：5-羟色胺再摄取抑制剂 达泊西汀 (S)-(+)-(N N-二甲氨基)-3-(萘基-1-氧基)苯丙胺 

分 类 号：O69[理学—化学]