5-溴-2-甲基苯并噻唑的合成研究  

Synthesis of 5-Bromo-2-methylbenzothiazole

作　　者：陈群[1] 程进[1] 

机构地区：[1]常州工程职业技术学院化学工程系,江苏常州213164

出　　处：《化学试剂》2015年第2期189-192,共4页Chemical Reagents

摘　　要：以2,4-二溴硝基苯为原料,在相转移催化剂条件下,经过硫代、还原、酸化、酰化和环合等5步反应制备得到目标化合物,产物收率≥59.1%。考察了Na2S2滴加时间、还原反应时间、酸化时间和酰化产物中水分含量对产物收率的影响。适宜的反应条件分别是:Na2S2滴加时间为5 h,还原反应时间为4 h,酸化时间为35 min,酰化产物含水量≤4%。5-Bromo-2-methylbenzothiazole was synthesized from 2,4-dibromonitrobenzene by thionation,reduction,acidification,acylation and cyclization under the presence of phase transfer catalyst with an overall yield of over 59. 1%. The conditions were investigated via dropping speed of Na2S2,reduction time,acidification time,water contents of acylation and molar ratio of raw materials. The optimum production conditions are as follows： dropping speed of Na2S25 h,reduction time 4 h,acidification time 35 min,water content of acylation ≤4%.

关 键 词：2 4-二溴硝基苯 硫代 还原 酰化 环合 

分 类 号：O625.6[理学—有机化学]