在慢性阻塞性肺疾病不同分期中血清胎盘生长因子水平的变化  

Levels of serum placenta growth factor in different stages of chronic obstructive pulmonary disease

作　　者：荣淑慧 宋艳红[1] 靳国田 于雪梅[1] 赵尚德[1] 李维才[2] 

机构地区：[1]内蒙古医科大学第四附属医院呼吸科,内蒙古包头014030 [2]内蒙古医科大学附属医院儿科,内蒙古呼和浩特010000

出　　处：《中国临床研究》2015年第2期159-162,共4页Chinese Journal of Clinical Research

基　　金：内蒙古包头市科技局社会发展支撑项目(2011S2012-09-01)

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)急性加重期和稳定期血清中胎盘生长因子(Pl GF)的水平,及其与高敏C反应蛋白(hs-CRP)和第一秒用力呼气容积(FEV1)的相关性。方法连续选择2011年12月至2012年10月就诊的COPD患者60例,其中急性加重期组和稳定期组各30例,同时纳入30例健康体检者为正常对照组。采用ELISA法和胶体金法,分别测定血清中Pl GF和hs-CRP的水平,并检测FEV1。所得资料采用非参数法和线性相关进行比较分析。结果 (1)3组Pl GF浓度的秩均值比较,急性加重期组高于稳定期组和正常对照组(P均<0.01),稳定期组亦高于正常对照组(P<0.01)。(2)3组hs-CRP浓度的秩均值比较,急性加重期组高于稳定期组和正常对照组(P均<0.01),稳定期组亦高于正常对照组(P<0.01)。(3)3组FEV1占预计值百分比的秩均值比较,急性加重期组均低于稳定期组和正常对照组(P均<0.01),稳定期组亦比正常对照组低(P<0.01)。(4)急性加重期组和稳定期组Pl GF与FEV1均呈负相关(r=-0.465,-0.402,P均<0.05)。结论 COPD患者尤其是急性期患者血清中Pl GF的水平增高,并与FEV1呈负相关,提示Pl GF参与COPD的发病过程。Objective To investigate the levels of serum placental growth factor（ Pl GF） in patients with chronic obstructive pulmonary disease（ COPD） at acute exacerbation（ AECOPD） stage and stable stage,and its association with high-sensitivity C-reactive protein（ hs-CRP） and forced expiratory volume in first second（ FEV1）. Methods The consecutive 60 COPD patients including 30 cases of AECOPD and 30 cases of stable stage presented between December 2011 and October2012 were enrolled in this study. At the same time,30 healthy volunteers were selected as control group. The levels of serum Pl GF and hs-CRP were measured by enzyme-linked immunosorbent assay（ ELISA） and colloidal gold method,respectively. The FEV1 was also detected. The obtained data were analyzed using nonparametric test and linear correlation analysis. Results The mean rank of serum concentration of Pl GF in AECOPD group was higher than those in stable stage group and control group（ all P〈0. 01）,and it in stable stage group was higher than that in control group（ P〈0. 01）. The mean rank of serum hs-CRP concentration in AECOPD group was higher than those in stable stage group and control group（ all P〈0. 01）,and it in stable stage group was higher than that in control group（ P〈0. 01）. The mean rank of the percentage of FEV1 value in predicted value（ FEV1% pred） in AECOPD group was lower than those in stable stage group and control group（ all P〈0. 01）,and it in stable stage group was lower than that in control group（ P〈0. 01）. In AECOPD group and stable stage group,the levels of serum Pl GF were all negatively correlated with FEV1,respectively（ r =-0. 465,-0. 402,all P〈0. 05）. Conclusions Serum concentration of Pl GF increases and is correlated with FEV1 in COPD especially AECOPD patients,suggesting Pl GF may be involved in the pathogenesis of COPD.

关 键 词：慢性阻塞性肺疾病 胎盘生长因子 血管内皮生长因子 高敏C反应蛋白 第一秒用力呼气容积 

分 类 号：R563[医药卫生—呼吸系统]