细菌感染中WBC、N%、CRP及PCT检测的比较分析  

Comparative analysis of WBC,N%,CRP and PCT detection in bacterial infections

作　　者：张庆勇[1,2] 鲜胜[1,2] 曾晶晶[1,2] 李春龙[1,2] 罗春华[1,2] 

机构地区：[1]三峡大学第一临床医学院 [2]宜昌市中心人民医院检验科,湖北宜昌443003

出　　处：《国际检验医学杂志》2015年第3期289-290,共2页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81202303)

摘　　要：目的对白细胞计数(WBC)、中性粒细胞百分率(N%)、C反应蛋白(CRP)和降钙素原(PCT)检测在临床细菌感染中的应用价值进行比较分析。方法随机抽取细菌感染性疾病患者70例和同期收治的非细菌感染性疾病患者81例作为研究对象,对其展开WBC、N%、CRP及PCT检测,对比分析检测结果。结果与非细菌感染组比较,细菌感染组WBC、N%、CRP和PCT均升高,差异有统计学意义(P<0.05);细菌感染组WBC、N%、CRP和PCT阳性率明显高于非细菌感染组,差异有统计学意义(P<0.05)。细菌感染组组内比较发现,N%、CRP和PCT阳性率明显高于WBC,差异有统计学意义(P<0.05);CRP阳性率高于PCT,差异有统计学意义(P<0.05),但非细菌感染组CRP阳性率较高,PCT阳性率较低,提示CRP假阳性率较高,特异性低,PCT假阳性率较低,特异性高。结论 WBC、N%、CRP和PCT检测在临床细菌感染中均有较大的临床价值,N%、CRP和PCT对细菌感染的诊断要优于WBC。其中,CRP更为敏感,但特异性低,而PCT特异性高,更适用于细菌感染的诊断。Objective To investigate and compare the applications of white blood cell count（WBC）,neutrophil percentage（N%）,C reactive protein（CRP）and procalcitonin（PCT）in the detection of bacterial infections.Methods Patients were randomly recruited in the study,70 patients with bacterial infection disease were recruited in the study as bacterial infection group,81 patients without bacterial infection were enrolled as no infection group.WBC,N%,CRP and PCT were detected,then comparative analysis of test results performed.Results Compared with no bacterial infection group,WBC,N%,CRP and PCT were increased in bacterial infection group（P〈0.05）,CRP and PCT increased obviously.The positive rate of WBC,N%,CRP and PCT in bacterial infection group was significantly higher than that of no bacterial infection group（P〈0.05）.In the bacterial infection group,the positive rate of N%,CRP and PCT was significantly higher than that of WBC（P〈0.05）,the positive rate of CRP was higher than PCT（P〈0.05）.But the positive rate of CRP was relatively high,and PCT was low in no bacterial infection group,suggesting that the false positive rate of CRP was higher,while that of PCT was lower,which had higher specificity.Conclusion WBC,N%,CRP and PCT all have clinical value for bacterial infections diagnosis.For the diagnosis of bacterial infections,N%,CRP and PCT is superior to WBC.CRP is more sensitive,but less specific,therefore,PCT with higher specificity was more suitable in the diagnosis of bacterial infections.

关 键 词：细菌感染 白细胞计数 C反应蛋白 降钙素原 

分 类 号：R446.1[医药卫生—诊断学]