肌钙蛋白I联合氨基末端脑钠肽前体检测在急性心肌梗死诊断中的临床意义  

The clinical significance of troponin I and N-terminal pro-brain natriuretic peptide detection in the diagnosis of acute myocardial infarction

作　　者：钟妙容[1] 王健[1] 杨海[1] 张慧娟[1] 杨小兰[1] 陈远东[1] 

机构地区：[1]惠州市第三人民医院,广东516000

出　　处：《国际检验医学杂志》2015年第3期365-366,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨肌钙蛋白I联合氨基末端脑钠肽前体(NT-proBNP)检测在急性心肌梗死诊断中的临床意义。方法对89例急性心肌梗死患者及102例非急性心肌梗死患者全血肌钙蛋白I和NT-proBNP进行检测。结果急性心肌梗死组全血肌钙蛋白I和NT-proBNP水平显著高于非急性心肌梗死组(P<0.05);同时,肌钙蛋白I联合NT-proBNP检测可将诊断AMI的灵敏度和特异度分别提高到88.8%和93.1%。结论早期联合检测全血cTnI与NT-proBNP水平,可以提高急性心肌梗死早期诊断的灵敏度和特异度。Objective To investigate the clinical significance of troponin I and N-terminal pro-brain natriuretic peptide detection in the diagnosis of acute myocardial infarction（AMI）.Methods The troponin I and N-terminal pro-brain natriuretic peptide（NTproBNP）were detected in 89 AMI patients（AMI group）and in 102non-AMI patients（non-AMI group）.Results The troponin I and NT-proBNP levels in AMI group were significant higher than those in non-AMI group,and the difference was statistically significant（P〈0.05）.Meanwhile,the combined detection of troponin I and NT-proBNP could increase the sensitivity and specificity of AMI′s early diagnosis to 88.8%and 93.1%.Conclusion Early and rapid detection of troponin I and NT-proBNP could significantly improve the early diagnosis of acute myocardial infarction in sensitivity and specificity.

关 键 词：肌钙蛋白I 氨基末端脑钠肽前体 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病] R446.1[医药卫生—内科学]