冠心病患者血清胱抑素C水平与冠状动脉病变程度相关性分析  

Relationship between serum cystatin C concentration and corornary lesions in patients with coronary heart disease

作　　者：王俊[1,2] 王邦宁[1] 王安才[2] 吴明[2] 王德国[2] 

机构地区：[1]安徽医科大学第一附属医院心血管内科,合肥230031 [2]皖南医学院附属弋矶山医院老年医学内科,安徽芜湖241001

出　　处：《重庆医学》2015年第4期475-477,481,共4页Chongqing medicine

基　　金：安徽省自然科学基金(1208085QH156)

摘　　要：目的观察肾功能正常的冠心病患者血清胱抑素C水平(Cys C)变化,探讨Cys C对冠状动脉病变严重程度的预测价值。方法检测316例肾功能正常的冠心病者及102例无冠心病者Cys C水平,从冠状动脉病变支数、冠状动脉狭窄程度、冠状动脉病变Gensini总评分三方面分析Cys C水平与冠心病之间的关系。结果冠心病组Cys C水平较对照组升高[(1.24±0.32)mg/L vs.(1.12±0.27)mg/L,P<0.01)];多支病变组Cys C水平较单支病变组显著升高[(1.31±0.31)mg/L vs.(1.20±0.32)mg/L,P<0.01];冠状动脉严重狭窄组Cys C水平较轻度狭窄组显著升高[(1.29±0.36)mg/Lvs.(1.16±0.23)mg/L,P<0.01],且冠心病患者Cys C与冠状动脉病变Gensini评分呈正相关(r=0.195,P<0.01)。结论冠心病患者Cys C水平增高,且与冠状动脉病变程度呈正相关。血清Cys C水平对冠状动脉病变程度具有一定的预测价值。Objective To observe the changes of serum cystatin C（Cys C）in patients with coronary heart disease（CHD）and normal kidney function,and evaluate the predictive value of Cys C concentration on coronary arterial lesions.Methods Serum levels of Cys C were detected in 316 patients with coronary heart disease and normal renal function.The relationship between serum 1evels of Cys C and coronary heart disease was evaluated from three aspects：the number of diseased vessels,the severity of diseased vessels and the CHD Gensini scores.Results The Cys C level in CHD group was significantly higher than that of non-CHD group[（1.24±0.32）mg/L vs.（1.12±0.27）mg/L,P〈0.01].Serum Cys C was significantly higher in the multi-vessel disease group than that of the single-vessel disease group[（1.31±0.31）mg/L vs.（1.20±0.32）mg/L,P〈0.01].Serum Cys C was significantly higher in the severe coronary artery stenosis group than in the mild stenosis group[（1.29±0.36）mg/L vs.（1.16±0.23）mg/L,P〈0.01].Cys C was positively correlated with the Gensini scores of coronary arterial lesion（r=0.195,P〈0.01）.ConclusionCys C levels increased in patients with coronary heart disease and normal renal function.Cys C was positively correlated with the Gensini scores of coronary arterial lesion.Serum Cys C levels has certain predictive value on coronary arterial lesions in patients with CHD.

关 键 词：冠心病 胱抑素C 冠状动脉病变 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]