环境内分泌干扰物的前列腺毒性研究进展  

Progress of toxicological studies in environmental endocrine disruptors on prostate

作　　者：黄冬妍[1,2] 吴建辉[2] 孙祖越[2] 

机构地区：[1]复旦大学药学院,上海201203 [2]中国生育调节药物毒理检测中心上海市计划生育科学研究所药理毒理学研究室

出　　处：《环境与健康杂志》2014年第9期837-840,共4页Journal of Environment and Health

基　　金：国家自然科学基金(21007041);上海市人才发展基金(201372);上海市科委研发公共服务平台项目(13DZ2291300)

摘　　要：近年来,环境内分泌干扰物(EDCs)对机体健康的不利影响已引起国内外研究者的极大关注,研究热点主要集中在EDCs的生殖毒性、神经毒性、免疫毒性以及致癌致畸作用等,而对前列腺的影响却较少有报道。笔者综述了常见的几类EDCs的前列腺毒性特点及其作用机制。这不仅为前列腺疾病的病因和发病机制提供理论依据,而且也是对EDCs毒性研究的一个补充。In recent years,the effects of environmental endocrine disruptors （EDCs） on human health have aroused great attention by researchers at home and abroad. Most of researches focus on reproductive toxicity,neurotoxicity,immune toxicity, carcinogenic and teratogenic effects of EDCs, whereas researches related to their effects on prostate are rarely reported. This paper summarized the toxicological feature and mechanism of several kinds of common endocrine disruptors which may have prostatic toxicity, and to provide theoretical support for the etiology and pathogenesis of prostate disease, and to complement the toxicity study of EDCs.

关 键 词：环境内分泌干扰物 前列腺增生 前列腺癌 毒性 

分 类 号：R994.6[医药卫生—毒理学]