中药新药毒性与抗癌效应研究  

Study on the Relationship between the Antitumor Effect and Toxicity of New Chinese Medicine

作　　者：任小巧[1] 高增平[1] 穆丽莎[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中医学报》2015年第1期7-9,共3页Acta Chinese Medicine

基　　金：国家中医药管理局中医药科技计划项目[国中医科(2008)01];北京中医药大学自主课题(2011-MZYY-01)

摘　　要：开发有效、低毒的抗癌中药的有效途径为:1采取药效与毒性相结合的研究方法,比较研究原药材、毒性成分(组分)和去毒药材的抗癌效果,建立科学的存效脱毒(减毒)方法。2建立符合中医理论的"抗癌中药癌症毒理实验动物模型"来评价抗癌中药的毒性。3以中医药理论为基础、以疗效为中心,确定抗癌新药的"效-毒"关系、建立与中医理论相适应的动物模型及多种靶点筛选模型,开展抗癌中药新药的疗效及机制研究。Effective way to develop effective and low toxicity anti-cancer Chinese medicine as follows： 1 Adopt combination medicine effects and toxicity in the evaluation of new antitumor drugs,then compare the pesticide effect of active compound,toxic constituents（ components） and medical material without toxicity,and sets up the scientific method of conserving effect and detoxification（ reducing toxicity）. 2Establish the anticancer medicine toxicology experiment animal model to evaluate the toxicity of anticancer Chinese medicine. 3Under the basic on traditional Chinese medicine（ TCM） basic theory and the core of curative effect,to determine the poisonfunction relationship of anti-cancer ingredients and construct animal screening model and multiple targets model matching TCM basic theory,in result of researching the effect-toxicity relationship of new antitumor drug in TCM. It is the main method of developing anticancer drugs from TCM with effectiveness and little toxic.

关 键 词：中药新药 存效脱毒(减毒) “抗癌中药癌症毒理学实验动物模型” “效-毒”关系 

分 类 号：R273[医药卫生—中西医结合]