曲美他嗪治疗冠状动脉慢血流现象的疗效  

Clinical effectiveness of trimetazidine in patients with coronary slow flow phenomenon

作　　者：刘涛[1] 李论[1] 郭张强[1] 高波[1] 曾晓辉[1] 顾晔[1] 

机构地区：[1]华中科技大学同济医学院附属普爱医院心内科,湖北武汉430033

出　　处：《上海医学》2014年第12期1041-1043,共3页Shanghai Medical Journal

基　　金：武汉市卫生和计划生育委员会临床医学科研基金资助(WX12C13)

摘　　要：目的评价曲美他嗪与传统药物结合治疗冠状动脉慢血流现象(CSFP)的疗效。方法将60例存在CSFP的患者随机分入治疗组和对照组,每组30例。治疗组患者在传统常规药物治疗的基础上加用曲美他嗪20mg/次,每日3次,口服12周;对照组患者只接受传统常规药物治疗。观察两组患者在治疗前后临床症状的改善情况和冠状动脉造影的血流变化。结果治疗组的心绞痛症状总显效率为60.0%(18/30),显著高于对照组的33.3%(10/30,P<0.05)。冠状动脉造影方面,治疗组CSFP改善的有效率为56.7%(17/30),显著高于对照组的30.0%(9/30,P<0.05)。结论在传统常规药物的基础上加用曲美他嗪治疗CSFP有效。Objective To assess the effect of trimetazidine in combination with conventional drug treatment on coronary slow flow phenomenon. Methods Sixty patients with coronary slow flow phenomenon were randomly divided into two groups： treatment group and control group （n = 30）. Conventional drug therapy and trimetazidine （20 mg, three times daily, oral administration for 12 weeks） were given in the treatment group, while only drug treatment was given in the control group. Clinical symptoms and blood flow were observed before and after treatment. Results The improvement rate of angina pectoris in the treatment group was significantly higher than that in the control group （60.0% [18/30] vs. 33.3% [10/30], P〈0.05）. The results of coronary angiography showed that blood flow was significantly increased in the treatment group as compared with the control group （56.7%[ 17/30] vs. 30.0%[9/30], P〈0, 05）. Conclusion Trimetazidine in combination with drug treatment is effective for coronary slow flow phenomenon. （Shanghai Med J, 2014, 37 = 1041-1043）

关 键 词：冠状动脉慢血流现象 曲美他嗪 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]