细胞药代动力学研究进展  

Research Progress in Cellular Pharmacokinetics

作　　者：倪苹[1] 张经纬[1] 刘嘉莉[1] 陈倩莹 王广基[1] 周芳[1] 

机构地区：[1]中国药科大学江苏省药物代谢动力学重点实验室,江苏南京210009

出　　处：《药学进展》2014年第12期881-885,共5页Progress in Pharmaceutical Sciences

基　　金：江苏省创新平台提升项目(No.BM2012012);十二五重大新药创制专项(No.2015ZX09501001)

摘　　要：经典的药物代谢动力学理论是建立在血浆药物浓度测定的基础上,常难以真实有效地预测体内药物的药效。很多药物必须穿透多重生物屏障,与细胞内的靶点相结合才能发挥药效。因此药代动力学研究迫切需要从"宏观"的血浆药物浓度深入到"微观"的细胞/亚细胞水平。综述细胞药代动力学研究领域取得的进展,重点介绍细胞药代动力学理论的提出、技术体系的建立及其在药物研发、筛选、临床方面的应用。Classical pharmacokinetic studies based on the determination of plasma drug concentrations may not be sufficient to predict pharmacological response in vivo. Many drugs must pass through multiple biological barriers before they reach the intracellular target. There is a pressing need to expand classic pharmacokinetics from macroscopic plasma concentration of drugs to the cellular or subcellular levels. The progress in cellular pharmacokinetics was summarized. The overview and strategies regarding current knowledge about cellular pharmacokinetics were focused illustrating the successful applications of it in drug development, screening, and clinical application.

关 键 词：细胞药代动力学 亚细胞分布 药效学/药动学模型 

分 类 号：R96[医药卫生—药理学]